Mc-Val-Cit-PAB-Cl

Names

[ Name ]:
Mc-Val-Cit-PAB-Cl

Biological Activity

[Description]:

Mc-Val-Cit-PAB-Cl is an ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Alkyl/ether

[References]

[1]. Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₉ClN₆O₆

[ Molecular Weight ]:
591.10

[ Storage condition ]:
-20°C

Mc-Val-Cit-PAB-Cl

Names

Biological Activity

Chemical & Physical Properties

Related Compounds