MC-Val-Cit-PAB-dimethylDNA31

Names

[ Name ]:
MC-Val-Cit-PAB-dimethylDNA31

Biological Activity

[Description]:

MC-Val-Cit-PAB-dimethylDNA31 has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Val-Cit-PAB-dimethylDNA31 is used for the antibody-drug conjugates (ADC) that are effective and stable in vitro and in vivo to treat various diseases or disorders[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> Drug-Linker Conjugates for ADC

[References]

[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇₈H₁₀₁N₁₀O₁₉

[ Molecular Weight ]:
1482.69

Related Compounds

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