159857-80-4
159857-80-4 structure
- Name: MC-Val-Cit-PAB-OH
- Chemical Name: N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N2-[4-(hydroxymethyl)phenyl]-L-ornithinamide
- CAS Number: 159857-80-4
- Molecular Formula: C28H40N6O7
- Molecular Weight: 572.65300
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2016-08-10 05:13:08
- Modify Date: 2024-01-03 14:40:58
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MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker.
| Name | N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N2-[4-(hydroxymethyl)phenyl]-L-ornithinamide |
|---|---|
| Synonyms | MC-Val-Cit-PAB |
| Description | MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker. |
|---|---|
| Related Catalog | |
| Target |
ADC linker[1] |
| References |
[1]. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
| Density | 1.276 |
|---|---|
| Molecular Formula | C28H40N6O7 |
| Molecular Weight | 572.65300 |
| Exact Mass | 572.29600 |
| PSA | 210.70000 |
| LogP | 3.27310 |
| Storage condition | 2-8℃ |
|
~94%
159857-80-4 |
| Literature: SEATTLE GENETICS, INC. Patent: WO2007/8848 A2, 2007 ; Location in patent: Page/Page column 108; 136; 137 ; |
