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Pseudouridine

Names

[ CAS No. ]:
1445-07-4

[ Name ]:
Pseudouridine

[Synonym ]:
(1S)-1,4-Anhydro-1-(2,4-dihydroxy-5-pyrimidinyl)-D-ribitol
2,4(1H,3H)-Pyrimidinedione, 5-β-D-ribofuranosyl-
Uracil, 5-β-D-ribofuranosyl-
β-Pseudouridine
D-Ribitol, 1,4-anhydro-1-C-(1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl)-, (1S)-
D-Ribitol, 1,4-anhydro-1-C-(2,4-dihydroxy-5-pyrimidinyl)-, (1S)-
(1S)-1,4-Anhydro-1-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-D-ribitol
5-(b-D-Ribofuranosyl)uracil
5-b-D-ribofuranosyl-Uracil
pseudouridine

Biological Activity

[Description]:

Pseudouridine, the most abundant modified nucleoside in non-coding RNAs, enhances the function of transfer RNA and ribosomal RNA by stabilizing RNA structure.

[Related Catalog]:

Natural Products >> Others
Research Areas >> Others

[Target]

Human Endogenous Metabolite


[References]

[1]. Carlile TM, et al. Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Nature. 2014 Nov 6;515(7525):143-6.


[Related Small Molecules]

3-Methyladenine | Hydrocortisone | Acetylcysteine(N-acetylcysteine) | Retinoic acid | Melatonine | Dinoprostone | Nicotinamide | Adenosine triphosphate | 4-Acetamidophenol | Prostaglandin E1 | Dehydroepiandrosterone | Corticosterone | Progesterone | Docosahexaenoic Acid | NAD+

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
598.4±60.0 °C at 760 mmHg

[ Melting Point ]:
231 °C(dec.)

[ Molecular Formula ]:
C9H12N2O6

[ Molecular Weight ]:
244.201

[ Flash Point ]:
315.7±32.9 °C

[ Exact Mass ]:
244.069534

[ PSA ]:
135.64000

[ LogP ]:
-3.77

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.697

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds