LIMK-IN-22j

Names

[ Name ]:
LIMK-IN-22j

[Synonym ]:
LIMK-IN-22j

Biological Activity

[Description]:

LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC50s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> LIM Kinase (LIMK)

Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK

Signaling Pathways >> Stem Cell/Wnt >> ROCK

Signaling Pathways >> TGF-beta/Smad >> ROCK

[Target]

LIMK1:0.9 nM (IC50)

LIMK2:0.5 nM (IC50)

ROCK1:260 nM (IC50)

ROCK2:2700 nM (IC50)

[References]

[1]. Harrison BA, et.al. Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52(21):6515-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₁BrN₈

[ Molecular Weight ]:
453.34

[ Exact Mass ]:
452.10700

[ PSA ]:
96.23000

[ LogP ]:
3.56438

Safety Information

[ Hazard Codes ]:
Xn

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.