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LIMK-IN-22j

Names

[ CAS No. ]:
1116571-01-7

[ Name ]:
LIMK-IN-22j

[Synonym ]:
LIMK-IN-22j

Biological Activity

[Description]:

LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC50s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Cell Cycle/DNA Damage >> LIM Kinase (LIMK)
Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK
Signaling Pathways >> Stem Cell/Wnt >> ROCK
Signaling Pathways >> TGF-beta/Smad >> ROCK

[Target]

LIMK1:0.9 nM (IC50)

LIMK2:0.5 nM (IC50)

ROCK1:260 nM (IC50)

ROCK2:2700 nM (IC50)


[References]

[1]. Harrison BA, et.al. Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52(21):6515-8.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H21BrN8

[ Molecular Weight ]:
453.34

[ Exact Mass ]:
452.10700

[ PSA ]:
96.23000

[ LogP ]:
3.56438

Safety Information

[ Hazard Codes ]:
Xn

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds