1116571-01-7

1116571-01-7 structure

Name: LIMK-IN-22j
Chemical Name: (2S)-N-(3-Bromophenyl)-N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2 ,3-d]pyrimidin-4-yl)-1-piperazinecarboximidamide
CAS Number: 1116571-01-7
Molecular Formula: C₂₀H₂₁BrN₈
Molecular Weight: 453.34
Catalog: Signaling Pathways Cell Cycle/DNA Damage LIM Kinase (LIMK)
Create Date: 2016-10-31 17:57:56
Modify Date: 2024-01-29 15:50:28
LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC50s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research[1].

Name	(2S)-N-(3-Bromophenyl)-N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2 ,3-d]pyrimidin-4-yl)-1-piperazinecarboximidamide
Synonyms	LIMK-IN-22j

Description	LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC50s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> LIM Kinase (LIMK) Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
Target	LIMK1:0.9 nM (IC50) LIMK2:0.5 nM (IC50) ROCK1:260 nM (IC50) ROCK2:2700 nM (IC50)
References	[1]. Harrison BA, et.al. Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52(21):6515-8.

Hazard Codes	Xn

853763-68-5

1116570-96-7

~58%

1116571-01-7

Literature: US2009/42893 A1, ; Page/Page column 9; 10 ; US 20090042893 A1

Precursor 2
853763-68-5 1116570-96-7
DownStream 0