3-Maleimidopropionic acid
3-Maleimidopropionic acid structure
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Common Name | 3-Maleimidopropionic acid | ||
|---|---|---|---|---|
| CAS Number | 7423-55-4 | Molecular Weight | 169.135 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 382.5±25.0 °C at 760 mmHg | |
| Molecular Formula | C7H7NO4 | Melting Point | 103-106 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 185.1±23.2 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with (89)Zr(4+): comparison with desferrioxamine-B.
Dalton Trans. 44(11) , 4884-900, (2015) Due to its long half-life (78 h) and decay properties (77% electron capture, 23% β(+), Emax = 897 keV, Eav = 397 keV, Eγ = 909 keV, Iγ = 100%) (89)Zr is an appealing radionuclide for immunoPET imaging with whole IgG antibodies. Derivatives of the siderophore ... |
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Extracellular Subunit Interactions Control Transitions between Functional States of Acid-sensing Ion Channel 1a.
J. Biol. Chem. 290 , 17956-66, (2015) Acid-sensing ion channels (ASICs) are neuronal, voltage-independent Na(+) channels that are transiently activated by extracellular acidification. They are involved in pain sensation, the expression of fear, and in neurodegeneration after ischemic stroke. Our ... |
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Selective and Sensitive Sensing of Flame Retardant Chemicals Through Phage Display Discovered Recognition Peptide.
Nano Lett. 15 , 7697-703, (2015) We report a highly selective and sensitive biosensor for the detection of an environmentally toxic molecule, decabrominated diphenyl ether (DBDE), one of the most common congeners of the polybrominated frame retardants (polybrominated diphenyl ether (PBDE)), ... |
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Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols.
Nat. Commun. 6 , 5686, (2015) Friedreich's ataxia is a severe neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein that stimulates iron-sulfur (Fe-S) cluster biogenesis. In mammals, the primary steps of Fe-S cluster assembly are performed by th... |
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Maleimidyl magnetic nanoplatform for facile molecular MRI.
Nanotechnology 25(27) , 275102, (2014) In this study, we developed the maleimidyl magnetic nanoplatform, which enables functional targeting of a biomarker-specific moiety for molecular imaging via MRI. The maleimide group of the maleimidyl magnetic nanoplatform is conjugated with a thiol group wit... |
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Studies on immunoassays of peptide factors. V. Synthesis of cholecystokinin-58-[1-11]/iso-1-cytochrome c conjugate.
Hoppe. Seylers. Z. Physiol. Chem. 368 , 855, (1987) In previous studies on model compounds we have found that the maleimide function is sufficiently stable under the conditions of peptide synthesis to allow its incorporation at preselected positions of a peptide chain in earlier steps of the synthetic route. T... |
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Controlled release of free doxorubicin from peptide-drug conjugates by drug loading.
J. Control. Release 191 , 123-30, (2014) Covalent modification of a drug with a peptide moiety has been extensively used as an effective strategy to improve the drug's therapeutic outcome. One important consideration in the design of such a prodrug is the release of the free drug from the covalently... |
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Preparation of size tunable giant vesicles from cross-linked dextran(ethylene glycol) hydrogels.
Chem. Commun. (Camb.) 50(16) , 1953-5, (2014) We present a novel chemically cross-linked dextran-poly(ethylene glycol) hydrogel substrate for the preparation of dense vesicle suspensions under physiological ionic strength conditions. These vesicles can be easily diluted for individual study. Modulating t... |
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Proton-mediated conformational changes in an acid-sensing ion channel.
J. Biol. Chem. 288(50) , 35896-903, (2013) Acid-sensing ion channels are cation channels activated by external protons and play roles in nociception, synaptic transmission, and the physiopathology of ischemic stroke. Using luminescence resonance energy transfer (LRET), we show that upon proton binding... |
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A molecular umbrella approach to the intracellular delivery of small interfering RNA.
Bioconjug. Chem. 22(11) , 2210-6, (2011) A series of diwalled and tetrawalled molecular umbrellas have been synthesized using cholic acid, spermidine, and lysine as starting materials. Coupling of these molecular umbrellas to an octaarginine peptide afforded agents that were capable of promoting the... |