Menthol
Menthol structure
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Common Name | Menthol | ||
|---|---|---|---|---|
| CAS Number | 89-78-1 | Molecular Weight | 156.265 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 215.4±8.0 °C at 760 mmHg | |
| Molecular Formula | C10H20O | Melting Point | 34-36 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 93.3±0.0 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Carbopol 934, 940 and Ultrez 10 as viscosity modifiers of palm olein esters based nano-scaled emulsion containing ibuprofen.
Pak. J. Pharm. Sci. 26(1) , 75-83, (2013) Micro-emulsions and sometimes nano-emulsions are well known candidates to deliver drugs locally. However, the poor rheological properties are marginally affecting their acceptance pharmaceutically. This work aimed to modify the poor flow properties of a nano-... |
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Activation of human 5-hydroxytryptamine type 3 receptors via an allosteric transmembrane site.
Mol. Pharmacol. 87(1) , 87-95, (2015) In common with other members of the Cys-loop family of pentameric ligand-gated ion channels, 5-hydroxytryptamine type 3 receptors (5-HT3Rs) are activated by the binding of a neurotransmitter to an extracellular orthosteric site, located at the interface of tw... |
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Toxicity assessment of tobacco products in vitro.
Altern. Lab. Anim. 43 , 39-67, (2015) Driven by new regulatory demands to demonstrate risk reduction, the toxicity assessment of tobacco products increasingly employs innovative in vitro methods, including biphasic cell and tissue cultures exposed to whole cigarette smoke at the air-liquid interf... |
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Corneal sensory nerve activity in an experimental model of UV keratitis.
Invest. Ophthalmol. Vis. Sci. 55(6) , 3403-12, (2014) To produce in guinea pigs a UV-induced keratitis, to analyze the effects of this pathology on corneal nerve activity.In anesthetized animals, one eye was exposed to 254 nm UV-C radiation (500-1000 mJ/cm(2)), excised 24 to 48 hours later and superfused in vitr... |
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Effects of menthol on tobacco smoke exposure, nicotine dependence, and NNAL glucuronidation.
Cancer Epidemiol. Biomarkers Prev. 18(1) , 35-41, (2009) Menthol is a controversial cigarette additive because its physiologic or pharmacologic effects may possibly increase the risk for cancer and its targeted market is the Black community. In a community-based cross-sectional study on 525 Black and White voluntee... |
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Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves.
Life Sci. 92(6-7) , 359-67, (2013) Transient receptor potential (TRP) vanilloid-1 (TRPV1) and melastatin-8 (TRPM8) channels play a role in transmitting sensory information in primary-afferent neurons. TRPV1 agonists at high concentrations inhibit action potential conduction in the neurons and ... |
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A menthol-based solid dispersion technique for enhanced solubility and dissolution of sulfamethoxazole from an oral tablet matrix.
AAPS PharmSciTech 16 , 771-86, (2015) A menthol-based solid dispersion was designed to improve the intrinsic solubility of the poorly soluble sulfamethoxazole- a class II drug molecule of Biopharmaceutics Classification System (BCS) displaying widespread antibacterial activity. Solid dispersions ... |
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1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.
Mol. Pain 8 , 86, (2012) Essential oils are often used in alternative medicine as analgesic and anti-inflammatory remedies. However, the specific compounds that confer the effects of essential oils and the molecular mechanisms are largely unknown. TRPM8 is a thermosensitive receptor ... |
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Effect of menthol in experimentally induced ulcers: pathways of gastroprotection.
Chem. Biol. Interact. 206(2) , 272-8, (2013) Based on ethnopharmacological indications that Mentha species may be used in the treatment of gastrointestinal diseases, this study aimed to characterize the gastroprotective mechanisms of menthol (ME), the major compound of the essential oil from species of ... |
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What happens if people start drinking mouthwash as surrogate alcohol? A quantitative risk assessment.
Food Chem. Toxicol. 51 , 173-8, (2013) Mouthwash ingestion has been observed in settings of restricted availability to alcoholic beverages such as in hospitals, prisons or military establishments. The literature offers limited evidence that ingredients of mouthwash may have health effects above th... |