DEQUALINIUM IODIDE
DEQUALINIUM IODIDE structure
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Common Name | DEQUALINIUM IODIDE | ||
|---|---|---|---|---|
| CAS Number | 2019-42-3 | Molecular Weight | 710.47400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H40I2N4 | Melting Point | >300ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Antimicrobial topical agents used in the vagina.
Curr. Probl. Dermatol. 40 , 36-47, (2011) Vaginally applied antimicrobial agents are widely used in the vagina in women with lower genital tract infections. An 'antimicrobial' is a general term that refers to a group of drugs that are effective against bacteria, fungi, viruses and protozoa. Topical t... |
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Dequalinium induces cytotoxicity in human leukemia NB4 cells by downregulation of Raf/MEK/ERK and PI3K/Akt signaling pathways and potentiation of specific inhibitors of these pathways.
Leuk. Res. 38(7) , 795-803, (2014) Delocalized lipophilic cation dequalinium (DQA) selectively accumulates in mitochondria and displays anticancer activity in different malignancies. Our previous studies indicate a DQA-induced cytotoxicity in human acute promyelocytic leukemia NB4 cells by ear... |
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N-palmitoyl-ethanolamine (PEA) induces peripheral antinociceptive effect by ATP-sensitive K+-channel activation.
J. Pharmacol. Sci. 118(2) , 156-60, (2012) Although the antinociceptive effects of N-palmitoyl-ethanolamine (PEA) were first characterized nearly 50 years ago, the identity of the mechanism that mediates these actions has not been elucidated. The present study investigated the contribution of K(+) cha... |
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New method for the quantification of dequalinium cations in pharmaceutical samples by absorption and fluorescence diode array thin-layer chromatography.
J. Chromatogr. A. 1216(25) , 5052-6, (2009) A diode array HPTLC method for dequalinium chloride in pharmaceutical preparations is presented. For separation a Nano TLC silica gel plate (Merck) is used with the mobile phase methanol-7.8% aqueous NH(4)(+)CH(3)COO(-) (17:3, v/v) over a distance of 6 cm. De... |
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Exercise-induced cardioprotection is impaired by anabolic steroid treatment through a redox-dependent mechanism
J. Steroid Biochem. Mol. Biol. 138 , 267-72, (2013) • Supraphysiological DECA treatment on heart redox metabolism was investigated during I/R in sedentary and exercised rats. • DECA reduced SOD and GR activities in exercised rats upon reperfusion. • Reduced antioxidant enzyme activities promote heart thiol oxi... |
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Disintegration of amyloid fibrils of α-synuclein by dequalinium
Biochim. Biophys. Acta 1780(10) , 1156-61, (2008) α-Synuclein is the major amyloidogenic component observed in the Lewy bodies of Parkinson's disease. Amyloid fibrils of α-synuclein prepared in vitro were instantaneously disintegrated by dequalinium (DQ). Double-headed cationic amphipathic structure of DQ wi... |
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Dequalinium induces apoptosis in peripheral blood mononuclear cells isolated from human chronic lymphocytic leukemia.
Invest. New Drugs 29(6) , 1156-63, (2011) B-cell chronic lymphocytic leukemia (B-CLL) is an abnormal neoplasic proliferation of B cells, which accumulate mainly in the bone marrow and blood preventing both B cells development in the lymph nodes and the ability to fight against infection. The antitumo... |
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Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain.
Apoptosis 16(5) , 460-7, (2011) Inhibitor of apoptosis proteins (IAPs) regulate the activity of caspases in apoptosis. The human X chromosome-encoded IAP (XIAP) is one of the more potent members of the IAP family and it has been described as a central regulator of apoptosis. Thus, molecules... |
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Dequalinium induces human leukemia cell death by affecting the redox balance.
Leuk. Res. 35(10) , 1395-401, (2011) Dequalinium, an amphiphilic quinolinium derivative, selectively accumulates in mitochondria and displays anticancer activity in cells from different malignancies. Previous studies indicate a differential DQA-induced cytotoxicity in NB4 and K562 human leukemia... |
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Mechanisms of relaxing response induced by rat/mouse hemokinin-1 in porcine coronary arteries: roles of potassium ion and nitric oxide.
Eur. J. Pharmacol. 569(1-2) , 119-25, (2007) Rat and mouse hemokinin-1(r/m hemokinin-1) is a recently described member of the tachykinin family whose cardiovascular functions are not fully understood. In this study, we investigated the mechanisms of the relaxing response induced by r/m hemokinin-1 in is... |