The Journal of Steroid Biochemistry and Molecular Biology 2013-11-01

Exercise-induced cardioprotection is impaired by anabolic steroid treatment through a redox-dependent mechanism

Elen A. Chaves, Rodrigo S. Fortunato, Denise P. Carvalho, José Hamilton M. Nascimento, Marcus F. Oliveira

Index: J. Steroid Biochem. Mol. Biol. 138 , 267-72, (2013)

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Abstract

• Supraphysiological DECA treatment on heart redox metabolism was investigated during I/R in sedentary and exercised rats. • DECA reduced SOD and GR activities in exercised rats upon reperfusion. • Reduced antioxidant enzyme activities promote heart thiol oxidation in exercised rats. • Anabolic androgenic steroid abuse cardiotoxicity involves redox imbalance in exercised animals.