Posaconazole
Posaconazole structure
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Common Name | Posaconazole | ||
|---|---|---|---|---|
| CAS Number | 171228-49-2 | Molecular Weight | 700.777 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 850.7±75.0 °C at 760 mmHg | |
| Molecular Formula | C37H42F2N8O4 | Melting Point | 170-1720C | |
| MSDS | Chinese USA | Flash Point | 468.3±37.1 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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In vivo and in vitro acquisition of resistance to voriconazole by Candida krusei.
Antimicrob. Agents Chemother. 58(8) , 4604-11, (2014) Candida krusei is an important agent of opportunistic infections that often displays resistance to several antifungals. We describe here the in vivo acquisition of resistance to voriconazole (VRC) by C. krusei isolates recovered from a leukemia patient during... |
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European Confederation of Medical Mycology (ECMM) epidemiological survey on invasive infections due to Fusarium species in Europe.
Eur. J. Clin. Microbiol. Infect. Dis. 33(9) , 1623-30, (2014) In order to better understand the epidemiology of fusariosis in Europe, a survey collecting information on the clinical characteristics of the patients infected by Fusarium as well as on the infecting isolates was launched. A total of 76 cases of invasive fus... |
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Simultaneous determination of seven azole antifungal drugs in serum by ultra-high pressure liquid chromatography and diode array detection.
Acta Clin. Belg. 69(1) , 53-61, (2014) Azole antifungals are a group of fungistatic agents that can be administered orally or parenterally. The determination of the concentrations of these antifungals (miconazole, fluconazole, ketoconazole, posaconazole, voriconazole, itraconazole, and its major a... |
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Multilocus sequence typing of Candida africana from patients with vulvovaginal candidiasis in New Delhi, India.
Mycoses 57(9) , 544-52, (2014) We investigated the prevalence of vulvovaginal candidiasis due to C. africana in an STD clinic in India and analysed the genetic relatedness of these C. africana isolates with those outside India. A total of 283 germ-tube-positive yeasts were identified by VI... |
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Calcineurin controls hyphal growth, virulence, and drug tolerance of Candida tropicalis.
Eukaryotic Cell 13(7) , 844-54, (2014) Candida tropicalis, a species closely related to Candida albicans, is an emerging fungal pathogen associated with high mortality rates of 40 to 70%. Like C. albicans and Candida dubliniensis, C. tropicalis is able to form germ tubes, pseudohyphae, and hyphae,... |
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Procedures and practices for the validation of bioanalytical methods using dried blood spots: a review.
Bioanalysis 6(18) , 2481-514, (2014) Dried blood spot (DBS) sampling, the collection of whole blood samples on paper, is an emerging technique used for bioanalytical methods. Several analytical challenges, such as possible effects of spotting volume, hematocrit and spot inhomogeneity are identif... |
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Automated high-content assay for compounds selectively toxic to Trypanosoma cruzi in a myoblastic cell line.
PLoS Negl. Trop. Dis. 9(1) , e0003493, (2015) Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, represents a very important public health problem in Latin America where it is endemic. Although mostly asymptomatic at its initial stage, after the disease becomes chronic, about a third of ... |
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Multi-azole-resistant Aspergillus fumigatus in the environment in Tanzania.
J. Antimicrob. Chemother. 69(11) , 2979-83, (2014) Azole resistance in Aspergillus fumigatus isolates has been increasingly reported with variable prevalence worldwide and is challenging the effective management of aspergillosis. Here we report the coexistence of both TR₃₄/L98H and TR₄₆/Y121F/T289A resistance... |
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Cryptic and rare Aspergillus species in Brazil: prevalence in clinical samples and in vitro susceptibility to triazoles.
J. Clin. Microbiol. 52(10) , 3633-40, (2014) Aspergillus spp. are among the most common causes of opportunistic invasive fungal infections in tertiary care hospitals. Little is known about the prevalence and in vitro susceptibility of Aspergillus species in Latin America, because there are few medical c... |
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Comparative evaluation of a new commercial colorimetric microdilution assay (SensiQuattro Candida EU) with MIC test strip and EUCAST broth microdilution methods for susceptibility testing of invasive Candida isolates.
J. Clin. Microbiol. 53(1) , 255-61, (2014) Candidemia is an important cause of morbidity and mortality in immunosuppressed patients. Candida isolates must be cultivated, identified, and tested for susceptibility. We compared the performance of a new colorimetric broth microdilution panel (SensiQuattro... |