(-)-Huperzine A
(-)-Huperzine A structure
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Common Name | (-)-Huperzine A | ||
|---|---|---|---|---|
| CAS Number | 102518-79-6 | Molecular Weight | 242.32 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 479.5±25.0 °C at 760 mmHg | |
| Molecular Formula | C15H18N2O | Melting Point | 211-216oC | |
| MSDS | Chinese USA | Flash Point | 243.8±23.2 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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An efficient total synthesis of (-)-huperzine A.
Org. Lett. 14(17) , 4446-9, (2012) The total synthesis of Lycopodium alkaloid (-)-huperzine A has been accomplished in 10 steps with 17% overall yield from commercially abundant (R)-pulegone. The synthetic route features an efficient synthesis of 4 via a Buchwald-Hartwig coupling reaction, a d... |
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Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways.
Pharmazie 69(7) , 532-6, (2014) The pregnane X receptor (PXR) is a key regulator of CYP3A4, which is involved in catalyzing the metabolic conversion of a number of endogenous substrates. In this study, we screened 22 compounds isolated from traditional Chinese herbal medicines using lucifer... |
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Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 904 , 65-72, (2012) Huperzine A (HupA) and Huperzine B (HupB) are natural alkaloids existed in Lycopodium plants. They both have potential clinical application for treating Alzheimer's Disease (AD). For the purpose of better utilizing the limited plant resources, a quick and low... |
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Investigating the antioxidant and acetylcholinesterase inhibition activities of Gossypium herbaceam.
Molecules 18(1) , 951-62, (2013) Our previous research showed that standardized extract from the flowers of the Gossypium herbaceam labeled GHE had been used in clinical trials for its beneficial effects on brain functions, particularly in connection with age-related dementia and Alzheimer's... |
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Free energy landscape for the binding process of Huperzine A to acetylcholinesterase.
Proc. Natl. Acad. Sci. U. S. A. 110(11) , 4273-8, (2013) Drug-target residence time (t = 1/k(off), where k(off) is the dissociation rate constant) has become an important index in discovering better- or best-in-class drugs. However, little effort has been dedicated to developing computational methods that can accur... |
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Preparation and in vitro and in vivo evaluation of HupA PLGA microsphere.
Pak. J. Pharm. Sci. 26(2) , 315-22, (2013) Acetylcholinesterase inhibitors (AChEIs), including Huperzine A (HupA), have been the mainstay of treatment for Alzheimer's disease (AD). However, AChEIs can cause gastrointestinal side effects, which has been related to the high Cmax and short tmax after ora... |
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Lumazine peptides penilumamides B-D and the cyclic pentapeptide asperpeptide A from a gorgonian-derived Aspergillus sp. fungus.
J. Nat. Prod. 77(7) , 1601-6, (2014) Three new lumazine peptides, penilumamides B-D (2-4), and one known analogue, penilumamide (1), together with a new cyclic pentapeptide, asperpeptide A (5), were isolated from the gorgonian-derived fungus Aspergillus sp. XS-20090B15. Among them, 2 was obtaine... |
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Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine.
Acta Pharmacol. Sin. 27(1) , 1-26, (2006) Huperzine A (HupA), a novel alkaloid isolated from the Chinese herb Huperzia serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase(AChE). Compared with tacrine, donepezil, and rivastigmine, HupA has better penetration through ... |
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Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors.
Curr. Top. Med. Chem 7(4) , 375-87, (2007) The naturally occurring alkaloid Huperzine A (HupA) is an acetylcholinesterase (AChE) inhibitor that has been used for centuries as a Chinese folk medicine in the context of its source plant Huperzia Serrata. The potency and relative safety of HupA rendered i... |
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Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia.
Chem. Biol. Interact. 175(1-3) , 396-402, (2008) Huperzine A (HupA), a novel Lycopodium alkaloid isolated from Chinese folk medicine Huperzia serrata (Qian Ceng Ta), is a potent, selective and well-tolerated inhibitor of acetylcholinesterase (AChE). It has been proven to significantly improve the learning a... |