Name | huperzine A |
---|---|
Synonyms |
5-Amino-1,2-dihydro-3H-pyrazol-3-one
(−)-Huperzine A MFCD01714949 (−)-Selagine (-)-Huperzine A 3-Amino-5-pyrazolone 3-Amino-1H-pyrazol-5-ol 3H-Pyrazol-3-one, 5-amino-1,2-dihydro- Huperzine A |
Description | Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value:Target: AChEHuperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease. |
---|---|
Related Catalog | |
References |
Density | 1.6±0.1 g/cm3 |
---|---|
Boiling Point | 479.5±25.0 °C at 760 mmHg |
Melting Point | 211-216oC |
Molecular Formula | C15H18N2O |
Molecular Weight | 242.32 |
Flash Point | 243.8±23.2 °C |
PSA | 58.88000 |
LogP | -0.22 |
Vapour Pressure | 0.0±1.2 mmHg at 25°C |
Index of Refraction | 1.741 |
Storage condition | −20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS06 |
---|---|
Signal Word | Danger |
Hazard Statements | H300 + H310 + H330-H315-H319-H335 |
Precautionary Statements | P260-P264-P280-P284-P301 + P310-P302 + P350 |
Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
Hazard Codes | T+ |
Risk Phrases | R26/27/28;R36/37/38 |
Safety Phrases | 26-36/37/39-45 |
RIDADR | UN 1544 6.1/PG 2 |
WGK Germany | 3 |
RTECS | PB9185700 |
HS Code | 2933990090 |
HS Code | 2933990090 |
---|---|
Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |