Polyoxyl 15 hydroxystearate
Polyoxyl 15 hydroxystearate structure
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Common Name | Polyoxyl 15 hydroxystearate | ||
|---|---|---|---|---|
| CAS Number | 70142-34-6 | Molecular Weight | 963.23800 | |
| Density | 1.048 g/cm3 at 20 °C | Boiling Point | N/A | |
| Molecular Formula | C47H94O19 | Melting Point | 25-30 °C | |
| MSDS | Chinese USA | Flash Point | 272 ℃ | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke.
Sci. Rep. 5 , 17956, (2015) Cyclooxygenase-2 (COX-2) is activated in response to ischemia and significantly contributes to the neuroinflammatory process. Accumulation of COX-2-derived prostaglandin E2 (PGE2) parallels the substantial increase in stroke-mediated blood-brain barrier (BBB)... |
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Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance.
Cancer Res. 51 , 897-902, (1991) A recently developed non-ionic surfactant called Solutol HS 15 (poly-oxyethylene esters of 12-hydroxystearic acid), with low toxicity in vivo, was shown to reverse completely the multidrug resistance of KB 8-5 and KB 8-5-11 human epidermoid carcinoma cells in... |
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Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: in vitro and in vivo results.
Int. J. Pharm. 365(1-2) , 143-149, (2009) The objective of the present study was to design a novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of a lipophilic drug, cyclosporine A (CsA). A CsA-loaded microemulsion was prepared using castor oil, Solutol HS 15 (su... |
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The encapsulation of DNA molecules within biomimetic lipid nanocapsules.
Biomaterials 30(18) , 3197-3204, (2009) Most of DNA synthetic complexes result from the self-assembly of DNA molecules with cationic lipids or polymers in an aqueous controlled medium. However, injection of such self-assembled complexes in medium like blood that differ from that of their formulatio... |
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Emulsifiers' composition modulates venous irritation of the nanoemulsions as a lipophilic and venous irritant drug delivery system.
AAPS PharmSci 10(3) , 1058-1064, (2009) In this study, a nanoemulsion (NE) system was investigated for intravenous delivery of lipophilic and venous irritant drugs. NEs were prepared to deliver diallyl trisulfide (DT) for systemic therapy of bacterial and fungal infection, egg phospholipid was chos... |
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Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs.
J. Pharmacol. Exp. Ther. 357 , 73-83, (2016) Cough remains a major unmet clinical need, and preclinical animal models are not predictive for new antitussive agents. We have investigated the mechanisms and pharmacological sensitivity of ozone-induced hypertussive responses in rabbits and guinea pigs. Ozo... |