Lovastatin
Lovastatin structure
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Common Name | Lovastatin | ||
|---|---|---|---|---|
| CAS Number | 75330-75-5 | Molecular Weight | 404.540 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 559.2±50.0 °C at 760 mmHg | |
| Molecular Formula | C24H36O5 | Melting Point | 175°C | |
| MSDS | Chinese USA | Flash Point | 185.3±23.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells.
Gynecol. Oncol. 135(2) , 333-41, (2014) Determine mechanisms responsible for enhanced statin efficacy in a novel statin combination we name STOX (STatin-OXysterol).Ovarian cancer cell lines were treated with combinations of statins and oxysterols. Cell viability was determined by a modified MTT ass... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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Lovastatin and perillyl alcohol inhibit glioma cell invasion, migration, and proliferation--impact of Ras-/Rho-prenylation.
Pharmacol. Res. 91 , 69-77, (2015) Alterations in small GTPase mediated signal transduction pathways have emerged as a central step in the molecular pathogenesis of glioblastoma (GBM), the most common malignant brain tumor in adults. Farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate ... |
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Curcumin enhances cell-surface LDLR level and promotes LDL uptake through downregulation of PCSK9 gene expression in HepG2 cells.
Mol. Nutr. Food. Res. 58(11) , 2133-45, (2014) Curcumin has been demonstrated as having numerous desirable characteristics, such as antioxidant, anti-inflammatory, and antiatherogenic activities. We report the hypocholesterolemic effect and molecular mechanism of curcumin.We found that curcumin enhanced L... |
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Curcumin inhibits TGFβ1-induced CCN2 via Src, JNK, and Smad3 in gingiva.
J. Dent. Res. 92(7) , 629-34, (2013) Transforming growth factor β (TGFβ) is a key regulator associated with the pathogenesis of gingival overgrowth (GO). Connective tissue growth factor (CTGF/CCN2) is overexpressed in GO tissues. CCN2 promotes and sustains fibrosis initiated by TGFβ. Previous st... |
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Chemical profiling and quantification of monacolins and citrinin in red yeast rice commercial raw materials and dietary supplements using liquid chromatography-accurate QToF mass spectrometry: Chemometrics application.
J. Pharm. Biomed. Anal. 100 , 243-53, (2014) Red yeast rice (RYR) is prepared by fermenting rice with various strains of the yeast Monascus spp of the Aspergillaceae family. Depending on the Monascus strains and the fermentation conditions, the products may contain monacolins, pigments and citrinin as s... |
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Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis.
Biochim. Biophys. Acta 1841(7) , 977-86, (2014) 2,3-Oxidosqualene is an intermediate in cholesterol biosynthesis and 2,3:22,23-dioxidosqualene act as the substrate for an alternative pathway that produces 24(S),25-epoxycholesterol which effects cholesterol homeostasis. In light of our previous findings con... |
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Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis.
J. Biol. Chem. 290 , 28822-33, (2015) Plasmalogen biosynthesis is regulated by modulating fatty acyl-CoA reductase 1 stability in a manner dependent on cellular plasmalogen level. However, physiological significance of the regulation of plasmalogen biosynthesis remains unknown. Here we show that ... |