Lovastatin

Modify Date: 2024-01-02 11:58:14

Lovastatin structure	Common Name	Lovastatin
	CAS Number	75330-75-5	Molecular Weight	404.540
	Density	1.1±0.1 g/cm3	Boiling Point	559.2±50.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₃₆O₅	Melting Point	175°C
	MSDS	Chinese USA	Flash Point	185.3±23.6 °C
	Symbol	GHS07	Signal Word	Warning

Use of Lovastatin

Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

Name	lovastatin
Synonym	More Synonyms

Description	Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Research Areas >> Cardiovascular Disease
Target	HMG-CoA reductase[1]
In Vitro	Lovastatin is an inactive lactone prodrug that must be chemically or enzymatically converted to its dihydroxy open-acid form in order to elicit inhibitory activity. Lovastatin in its hydroxy acid form is an exceptionally potent competitive inhibitor of liver HMG CoA reductase[1]. Lovastatin, other than its anticholesterol property, has diverse applications in the field of osteoporosis, neuro-degeneration, rheumatoid arthritis, antifungals and also is reported to reduce proliferation of lung cancer cells, breast cancer (MCF-7), liver cancer (HepG2). Lovastatin treatments show significant dose dependent cytotoxic effect on HeLa cells with IC50 value of 160 μg/mL. Lovastatin is effective to accelerate hydroxyl radical scavenging activity (54.06%) at an IC50 of 3601 μg/mL[2].
In Vivo	Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers[3]. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol[4].
Cell Assay	Hela cells are treated with lovastatin (0, 5, 10, 20, 40, 80, 160, 320 μg/mL) for 24 h. Cells treated with culture medium serves as a negative control. cell viability is measured using the MTT based colorimetric assay [2].
References	[1]. Alberts AW, et al. Discovery, biochemistry and biology of lovastatin. Am J Cardiol. 1988 Nov 11;62(15):10J-15J. [2]. Bhargavi S, et al. Purification of Lovastatin from Aspergillus terreus (KM017963) and Evaluation of its Anticancer and Antioxidant Properties. Asian Pac J Cancer Prev. 2016;17(8):3797-803. [3]. Frishman WH, et al. Lovastatin: an HMG-CoA reductase inhibitor for lowering cholesterol. Med Clin North Am. 1989 Mar;73(2):437-48. [4]. Tobert JA, et al. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2(7):517-26.

Density	1.1±0.1 g/cm3
Boiling Point	559.2±50.0 °C at 760 mmHg
Melting Point	175°C
Molecular Formula	C₂₄H₃₆O₅
Molecular Weight	404.540
Flash Point	185.3±23.6 °C
Exact Mass	404.256287
PSA	72.83000
LogP	4.07
Vapour Pressure	0.0±3.4 mmHg at 25°C
Index of Refraction	1.532
Storage condition	2-8°C
Water Solubility	0.0004 mg/mL at 25 ºC

Lovastatin MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25
RIDADR	3077
WGK Germany	3
RTECS	EK7907000
Packaging Group	III
Hazard Class	9
HS Code	2932999099

Precursor 2
CAS#:79691-11-5 6(R)-[2-[1,2,6,... CAS#:75225-51-3 LOVASTATIN HYDR...
DownStream 9
CAS#:79902-31-1 4-(TERT-BUTYLDI... CAS#:79902-63-9 Simvastatin CAS#:75225-50-2 Lovastatin hydr... CAS#:67-64-1 Acetone
CAS#:75-65-0 tert-Butanol CAS#:109273-98-5 Dehydro Lovastatin CAS#:75225-51-3 LOVASTATIN HYDR... CAS#:151006-15-4 (4R,6R)-4-hydro...
CAS#:132748-10-8 monacolin J acid

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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MEVINOLIN

LOVALIP

(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate

(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl-(2S)-2-methylbutanoat

Lovastatin

1,2,6,7,8,8a-Hexahydro-b,d-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid d-Lactone

2b,6a-Dimethyl-8a-(2-methyl-1-oxobutoxy)mevinic Acid Lactone

(+)-Mevinolin

Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-

(2S)-2-Methylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester

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(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate

MFCD00072164

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msd803

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Simvastatin Impurity 5

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Lovastatin
Price: ￥108.0/5g ￥348.0/25g ￥128.0/20mg
Purity: 95.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Lovastatin (MK-803)
Price: $200.0/100mg $400.0/250mg $800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Lovastatin
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: lovastatin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $66/10mM*1mLinDMSO

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