Dirithromycin
Dirithromycin structure
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Common Name | Dirithromycin | ||
|---|---|---|---|---|
| CAS Number | 62013-04-1 | Molecular Weight | 835.074 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 871.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C42H78N2O14 | Melting Point | 185 - 189ºC | |
| MSDS | Chinese USA | Flash Point | 481.0±34.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The new macrolide antibiotics: azithromycin, clarithromycin, dirithromycin, and roxithromycin.
Ann. Pharmacother. 26(1) , 46-55, (1992) To review the chemistry, antimicrobial spectrum, pharmacokinetics, clinical trials, adverse effects, and drug interactions of four new macrolide antibiotics: azithromycin, clarithromycin, dirithromycin, and roxithromycin.Information was obtained from comparat... |
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Pharmacokinetics of dirithromycin.
J. Antimicrob. Chemother. 31 Suppl C , 65-75, (1993) Dirithromycin is a new member of the macrolide class of antibiotics and has been developed for oral administration. Dirithromycin is a 14-membered lactone ring macrolide and is the C9-oxazine derivative of erythromycylamine. The human pharmacokinetics and cli... |
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Modulation of human polymorphonuclear neutrophil function by macrolides: preliminary data concerning dirithromycin.
J. Antimicrob. Chemother. 31 Suppl C , 51-64, (1993) Polymorphonuclear neutrophils (PMN) play a prominent role in the host response to infectious diseases. One major bactericidal mechanism used by these cells is the production of reactive oxygen species during what is referred to as the oxidative burst. However... |
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Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin.
.PubMed ID
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Dirithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy.
Drugs 48(4) , 599-616, (1994) Dirithromycin is a new macrolide with a spectrum and degree of in vitro antimicrobial activity similar to that of erythromycin. Compared with erythromycin, dirithromycin has a long elimination half-life enabling once-daily administration, and it also achieves... |
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Drug interactions of macrolides: emphasis on dirithromycin.
Ann. Pharmacother. 31(3) , 349-56, (1997) To describe the drug interactions of dirithromycin, a new macrolide, and to compare them with those of other macrolides.A literature search was performed using MEDLINE to identify articles published between January 1980 and July 1995 concerning the drug inter... |
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Dirithromycin: a new macrolide.
Ann. Pharmacother. 30(10) , 1141-9, (1996) To review the clinical microbiology and therapeutic use of dirithromycin, emphasizing comparative data between dirithromycin and the standard macrolide erythromycin, as well as clarithromycin and azithromycin.A MEDLINE search of English-language literature du... |
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Review and comparison of advanced-generation macrolides clarithromycin and dirithromycin.
Pharmacotherapy 19(4) , 404-15, (1999) We reviewed English-language clinical studies, abstracts, and review articles identified from MEDLINE searches from January 1966-August 1998, and bibliographies of identified articles to compare advanced-generation macrolides dirithromycin and clarithromycin ... |
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In vitro activity of azithromycin and dirithromycin against axenic Entamoeba histolytica.
Eur. J. Clin. Microbiol. Infect. Dis. 23(12) , 932-3, (2004)
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Comparative study of dirithromycin and azithromycin in the treatment of acute bacterial exacerbations of chronic bronchitis.
J. Chemother. 11(2) , 119-25, (1999) We compared the clinical and microbiological efficacy of dirithromycin with that of azithromycin in outpatients with acute bacterial exacerbations of chronic bronchitis who could be graded into stage III according to Ball's system of stratification. A total o... |