Fialuridine
Fialuridine structure
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Common Name | Fialuridine | ||
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| CAS Number | 69123-98-4 | Molecular Weight | 372.09 | |
| Density | 2.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C9H10FIN2O5 | Melting Point | 216-217ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Improved synthesis of 2'-deoxy-2'-[18F]-fluoro-1-beta-D-arabinofuranosyl-5-iodouracil ([18F]-FIAU).
Nucl. Med. Biol. 37(4) , 439-42, (2010) An improved synthesis of 2'-[(18)F]-fluoro-2'-deoxy-1-beta-D-arabinofuranosyl-5-iodouracil ([(18)F]-FIAU) has been developed. The method utilizes trimethylsilyl trifluoromethanesulfonate (TMSOTf) catalyzed coupling of 2-deoxy-2-[(18)F]-fluoro-1,3,5-tri-O-benz... |
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Imaging of a localized bacterial infection with endogenous thymidine kinase using radioisotope-labeled nucleosides.
Int. J. Med. Microbiol. 302(2) , 101-7, (2012) The importance of noninvasive imaging methods to bacterial infections is widely recognized. To obtain bacterial infection imaging with radioisotope-labeled nucleosides, bacterial thymidine kinase (tk) activities of Salmonella typhimurium with [(125)I]5-iodo-1... |
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Enhanced antitumor effects by combination gene therapy using MDR1 gene shRNA and HSV1-tk in a xenograft mouse model.
Cancer Lett. 291(1) , 83-9, (2010) The use of a novel therapeutic vector containing HSV1-thymidine kinase (HSV1-tk) and a short hairpin RNA for the MDR1 gene (shMDR) was proposed previously. We investigated the antitumor effects in an in vivo mouse model of colon cancer and assessed treatment ... |
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Herpes simplex virus thymidine kinase imaging in mice with (1-(2'-deoxy-2'-[18F]fluoro-1-β-D-arabinofuranosyl)-5-iodouracil) and metabolite (1-(2'-deoxy-2'-[18F]fluoro-1-β-D-arabinofuranosyl)-5-uracil).
Eur. J. Nucl. Med. Mol. Imaging 36(12) , 1987-93, (2009) FIAU, (1-(2'-deoxy-2'-fluoro-1-β-D-arabinofuranosyl)-5-iodouracil) has been used as a substrate for herpes simplex virus thymidine kinases (HSV-TK and HSV-tk, for protein and gene expression, respectively) and other bacterial and viral thymidine kinases for n... |
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Comparative study of cellular kinetics of reporter probe [(131)I]FIAU in neonatal cardiac myocytes after transfer of HSV1-tk reporter gene with two vectors.
Nucl. Med. Biol. 36(2) , 207-13, (2009) Reporter gene imaging is a promising approach for noninvasive monitoring of cardiac gene therapy. In this study, HSV1-tk (herpes simplex virus type 1 thymidine kinase) and FIAU (2'-fluoro-2'-deoxy-1-beta-d-arabinofuranosyl-5-iodouracil) were used as the repor... |
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In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas.
Nucleosides Nucleotides Nucleic Acids 27(1) , 57-66, (2008) Radioiodinated 5-iodo-1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)uracil (F *IAU) is most commonly used for noninvasive assessment of herpes simplex virus type 1 thymidine kinase (HSV-1-tk) gene expression. However, it does not permeate the intact blood-brain... |
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Effects of structural differences between radioiodine-labeled 1-(2'-fluoro-2'-deoxy-D-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2'-fluoro-2'-deoxy-d-ribofuranosyl)-5-iodouracil (FIRU) on HSV1-TK reporter gene imaging.
Appl. Radiat. Isot. 68(6) , 971-8, (2010) The goal of this investigation was to evaluate the effects of structural differences between FIAU and FIRU on their ability to serve as a potential tracer for reporter gene imaging. To examine the characteristics of different configurations of FIAU and FIRU, ... |
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5-[18F]Fluoroalkyl pyrimidine nucleosides: probes for positron emission tomography imaging of herpes simplex virus type 1 thymidine kinase gene expression
Nucl. Med. Biol. 36(1) , 29-38, (2009) Introduction The preliminary in vivo evaluation of novel 5-[ 18F]fluoroalkyl-2′-deoxyuridines ([ 18F]FPrDU, [ 18F]FBuDU, [ 18F]FPeDU; [ 18F] 1a−c, respectively) and 2′-fluoro-2′-deoxy-5-[ 18F]fluoroalkyl-1-β- d-arabinofuranosyl uracils ([ 18F]FFPrAU, [ 18F]FF... |
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In vivo trafficking and immunostimulatory potential of an intranasally-administered primary dendritic cell-based vaccine.
BMC Immunol. 11 , 60, (2010) Coccidioidomycosis or Valley fever is caused by a highly virulent fungal pathogen: Coccidioides posadasii or immitis. Vaccine development against Coccidioides is of contemporary interest because a large number of relapses and clinical failures are reported wi... |
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Biodistribution, cellular uptake and DNA-incorporation of the 2'-fluoro stabilized 5-iodo-2'-deoxyuridine analog 5-iodo-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil (FIAU).
Q. J. Nucl. Med. Mol. Imaging 52(3) , 305-16, (2008) 5-Iodo-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil (FIAU) has been used for non-invasive monitoring of gene therapy and as an antiviral agent experimentally and in patients. However, FIAU metabolism in tumor cells is largely unknown. Here, the biologica... |