Nuclear Medicine and Biology 2009-01-01

5-[18F]Fluoroalkyl pyrimidine nucleosides: probes for positron emission tomography imaging of herpes simplex virus type 1 thymidine kinase gene expression

Ann-Marie Chacko, Eric Blankemeyer, Brian P. Lieberman, Wenchao Qu, Hank F. Kung, Ann-Marie Chacko, Eric Blankemeyer, Brian P. Lieberman, Wenchao Qu, Hank F. Kung

Index: Nucl. Med. Biol. 36(1) , 29-38, (2009)

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Abstract

Introduction The preliminary in vivo evaluation of novel 5-[ 18F]fluoroalkyl-2′-deoxyuridines ([ 18F]FPrDU, [ 18F]FBuDU, [ 18F]FPeDU; [ 18F] 1a−c, respectively) and 2′-fluoro-2′-deoxy-5-[ 18F]fluoroalkyl-1-β- d-arabinofuranosyl uracils ([ 18F]FFPrAU, [ 18F]FFBuAU, [ 18F]FFPeAU; [ 18F] 1d−f, respectively) as probes for imaging herpes simplex virus type 1 thymidine kinase (HSV1- tk) gene expression is described.