Fialuridine

Modify Date: 2025-08-20 12:00:02

Fialuridine Structure
Fialuridine structure
 Common Name Fialuridine
CAS Number 69123-98-4 Molecular Weight 372.09
Density 2.2±0.1 g/cm3 Boiling Point N/A
Molecular Formula C9H10FIN2O5 Melting Point 216-217ºC
MSDS Chinese USA Flash Point N/A

 Use of Fialuridine


Fialuridine is a nucleoside analog with antiviral activity[1].

 Names

Name 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil
Synonym More Synonyms

 Chemical & Physical Properties

Density 2.2±0.1 g/cm3
Melting Point 216-217ºC
Molecular Formula C9H10FIN2O5
Molecular Weight 372.09
Exact Mass 371.961823
PSA 104.55000
LogP -0.32
Index of Refraction 1.685
Storage condition Refrigerator
Water Solubility DMSO: soluble5mg/mL, clear (warmed)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YQ9512500
CHEMICAL NAME :
Uracil, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-
CAS REGISTRY NUMBER :
69123-98-4
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H10-F-I-N2-O5
MOLECULAR WEIGHT :
372.11
WISWESSER LINE NOTATION :
T6NVMVJ EI A- BT5OTJ CF DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
9100 ug/kg/13W-I
TOXIC EFFECTS :
Liver - jaundice, other or unclassified Liver - liver function tests impaired Nutritional and Gross Metabolic - metabolic acidosis

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
40 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,3957,1982

 Safety Information

Hazard Codes Xi
Safety Phrases 24/25
RIDADR NONH for all modes of transport
RTECS YQ9512500
HS Code 2934999090

 Synthetic Route

3',5'-Di-O-benzoyl fialuridine structure

3',5'-Di-O-benz...

CAS#:97614-45-4

~94%

Fialuridine Structure

Fialuridine

CAS#:69123-98-4

Literature: RESprotech GmbH Patent: US2010/227834 A1, 2010 ; Location in patent: Page/Page column 18 ;
1-(O3-acetyl-O5-benzoyl-2-fluoro-β-D-2-deoxy-arabinofuranosyl)-1H-pyrimidine-2,4-dione structure

1-(O3-acetyl-O5...

CAS#:69124-02-3

~%

Fialuridine Structure

Fialuridine

CAS#:69123-98-4

Literature: US4211773 A1, ;
5-Bromo-3',5'-bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine structure

5-Bromo-3',5'-b...

CAS#:213136-12-0

~%

Fialuridine Structure

Fialuridine

CAS#:69123-98-4

Literature: Journal of Organic Chemistry, , vol. 73, # 21 p. 8236 - 8243
2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose structure

2-Deoxy-2-fluor...

CAS#:97614-43-2

~%

Fialuridine Structure

Fialuridine

CAS#:69123-98-4

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 40, p. 91 - 93
2-Deoxy-2-fluoro-alpha-D-arabinofuranosyl bromide 3,5-dibenzoate structure

2-Deoxy-2-fluor...

CAS#:97614-44-3

~%

Fialuridine Structure

Fialuridine

CAS#:69123-98-4

Literature: Journal of Organic Chemistry, , vol. 50, # 19 p. 3644 - 3647
2-(1'-Imidazoylsulfonyl)-1,3,5-tri-O-benzoyl-α-D-ribofuranose structure

2-(1'-Imidazoyl...

CAS#:97614-42-1

~%

Fialuridine Structure

Fialuridine

CAS#:69123-98-4

Literature: Journal of Organic Chemistry, , vol. 50, # 19 p. 3644 - 3647
((2R,3R,4S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate structure

((2R,3R,4S)-3-(...

CAS#:98855-71-1

~%

Fialuridine Structure

Fialuridine

CAS#:69123-98-4

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 40, p. 91 - 93

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles27

More Articles
Improved synthesis of 2'-deoxy-2'-[18F]-fluoro-1-beta-D-arabinofuranosyl-5-iodouracil ([18F]-FIAU).

Nucl. Med. Biol. 37(4) , 439-42, (2010)

An improved synthesis of 2'-[(18)F]-fluoro-2'-deoxy-1-beta-D-arabinofuranosyl-5-iodouracil ([(18)F]-FIAU) has been developed. The method utilizes trimethylsilyl trifluoromethanesulfonate (TMSOTf) cata...

Imaging of a localized bacterial infection with endogenous thymidine kinase using radioisotope-labeled nucleosides.

Int. J. Med. Microbiol. 302(2) , 101-7, (2012)

The importance of noninvasive imaging methods to bacterial infections is widely recognized. To obtain bacterial infection imaging with radioisotope-labeled nucleosides, bacterial thymidine kinase (tk)...

Enhanced antitumor effects by combination gene therapy using MDR1 gene shRNA and HSV1-tk in a xenograft mouse model.

Cancer Lett. 291(1) , 83-9, (2010)

The use of a novel therapeutic vector containing HSV1-thymidine kinase (HSV1-tk) and a short hairpin RNA for the MDR1 gene (shMDR) was proposed previously. We investigated the antitumor effects in an ...

 Synonyms

1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil
1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione
1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione
1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
Fialuridine
5-Iodo-2'-fluoroarauracil
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodo-
2'-Deoxy-2'-fluoro-5-iodouridine
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione
1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodouracil
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-
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