Applied Radiation and Isotopes 2010-06-01

Effects of structural differences between radioiodine-labeled 1-(2'-fluoro-2'-deoxy-D-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2'-fluoro-2'-deoxy-d-ribofuranosyl)-5-iodouracil (FIRU) on HSV1-TK reporter gene imaging.

Eun Jung Kim, Su Hee Hong, Tae Hyun Choi, Eun Ah Lee, Kyeong Min Kim, Kyo Chul Lee, Gwang Il An, Mohammed I El-Gamal, Gi Jeong Cheon, Chang Woon Choi, Sang Moo Lim

Index: Appl. Radiat. Isot. 68(6) , 971-8, (2010)

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Abstract

The goal of this investigation was to evaluate the effects of structural differences between FIAU and FIRU on their ability to serve as a potential tracer for reporter gene imaging. To examine the characteristics of different configurations of FIAU and FIRU, a series of evaluations were done on HSV1-TK gene-expressing cells and on mice with HSV1-TK gene-expressing tumor. The results showed that, as an imaging agent for HSV1-TK-expressing cells, radiolabeled FIAU was more efficient for in vivo imaging than FIRU.Copyright 2009 Elsevier Ltd. All rights reserved.