N-Benzhydrylpiperazine
N-Benzhydrylpiperazine structure
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Common Name | N-Benzhydrylpiperazine | ||
|---|---|---|---|---|
| CAS Number | 841-77-0 | Molecular Weight | 252.354 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 365.1±32.0 °C at 760 mmHg | |
| Molecular Formula | C17H20N2 | Melting Point | 90-93 °C | |
| MSDS | Chinese USA | Flash Point | 140.5±16.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Quantification of cyclizine and norcyclizine in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS).
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(9-10) , 605-9, (2011) A rapid and simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay was developed and validated for quantification of cyclizine and its main metabolite norcyclizine in human plasma. Samples were prepared by protein precipitation with acetonitri... |
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Oxidative metabolism of cinnarizine in rat liver microsomes.
Biochem. Pharmacol. 44(7) , 1471-4, (1992) The oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] to 1-(diphenylmethyl)piperazine (M-1), 1-(diphenylmethyl)-4-[3-(4'-hydroxyphenyl)-2-propenyl]piperazine (M-2), benzophenone (M-3) and 1-[4'-hydroxyphenyl)-phe... |
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The reactions of polyhalogenated-2-nitro-1, 3-butadiene with alkylthio, thiomorpholine and piperazine derivatives. Ibis C and Deniz NG.
Indian J. Chem. B 47(9) , 1407, (2008)
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Functionalization of sterically hindered o-benzoquinones: amino-substituted 3, 6-di (tert-butyl)-o-benzoquinones. Abakumov GA, et al.
Russ. Chem. Bull. 56(9) , 1849-56, (2007)
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Synthesis and in vitro antiproliferative activity of novel 1-benzhydrylpiperazine derivatives against human cancer cell lines.
Eur. J. Med. Chem. 44(3) , 1223-9, (2009) In order to explore the antiproliferative effect associated with the piperazine framework, several 1-benzhydrylpiperazine derivatives 8(a-d), 9(a-d) and 10(a-h) were synthesized. Variation in the functional group at N-terminal of the piperazine led to three s... |
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The pharmacokinetics and pharmacogenetics of the antiemetic cyclizine in palliative care patients.
J. Pain Symptom Manage. 43(3) , 540-8, (2012) Cyclizine, an antihistaminic antiemetic, is commonly used in palliative care. Its pharmacokinetics have been poorly studied, and its metabolic pathway is unknown but may involve the genetically controlled cytochrome P450 2D6 (CYP2D6). If this is the case, the... |
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Blood and urine concentrations of cyclizine by nitrogen-phosphorus gas-liquid chromatography.
J. Anal. Toxicol. 8(2) , 97-9, (1984) Gas-liquid chromatography with nitrogen-phosphorus detection was used to analyze blood and urine from a volunteer who ingested 50 mg of cyclizine hydrochloride. A peak blood cyclizine concentration of 69 ng/mL was observed 2 hr after drug administration, and ... |
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Sensitive high-performance liquid chromatographic determination of cyclizine and its demethylated metabolite, norcyclizine, in biological fluids using coulometric detection.
J. Chromatogr. B, Biomed. Appl. 672(1) , 172-7, (1995) An accurate, sensitive, selective and reproducible high-performance liquid chromatographic method with coulometric detection for the determination of cyclizine and its inactive demethylated metabolite, norcyclizine, in biological fluids has been developed. Th... |
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Determination of cyclizine and norcyclizine in plasma and urine using gas--liquid chromatography with nitrogen selective detection.
J. Chromatogr. A. 222(1) , 135-40, (1981)
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Biotransformation of cyclizine in greyhounds. 1: Identification and analysis of cyclizine and some basic metabolites in canine urine by gas chromatography-mass spectrometry.
Xenobiotica 32(9) , 795-807, (2002) 1. The partial in vivo biotransformation of Marezine [(cyclizine.HCl); 1-diphenylmethyl-4-methylpiperazine hydrochloride] in the racing greyhound and the excretion of the unconjugated and conjugated (Phase II) basic metabolites of cyclizine in canine urine ar... |