Journal of Analytical Toxicology 1984-01-01

Blood and urine concentrations of cyclizine by nitrogen-phosphorus gas-liquid chromatography.

D S Griffin, R C Baselt

Index: J. Anal. Toxicol. 8(2) , 97-9, (1984)

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Abstract

Gas-liquid chromatography with nitrogen-phosphorus detection was used to analyze blood and urine from a volunteer who ingested 50 mg of cyclizine hydrochloride. A peak blood cyclizine concentration of 69 ng/mL was observed 2 hr after drug administration, and the levels declined thereafter in a biphasic manner, with estimated half-lives of 7 and 24 hr for the early and late phases, respectively. The peak urine cyclizine concentration of 12.5 ng/mL was achieved at 4 hr after administration; only 0.01% of the dose was excreted in the 24 hr urine. Norcyclizine was not observed in blood or urine; however, the detectability of the method for this metabolite is poor relative to the parent drug.