parecoxib
parecoxib structure
|
Common Name | parecoxib | ||
|---|---|---|---|---|
| CAS Number | 198470-84-7 | Molecular Weight | 370.422 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C19H18N2O4S | Melting Point | 148.9-151° | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS08 |
Signal Word | Warning | |
|
Bsm1 vitamin D receptor polymorphism and calcium homeostasis following bariatric surgery.
J. Invest. Surg. 28(1) , 8-17, (2015) To evaluate the association between the Bsm1 vitamin D receptor polymorphism and the calcium-vitamin D-parathormone axis following bariatric surgery.This cross-sectional study included 86 morbidly obese patients, who underwent either gastric bypass or sleeve ... |
|
|
The effect of TSPP-mediated photodynamic therapy and Parecoxib in experimental tumours.
Life Sci. 117(2) , 75-83, (2015) The study investigated the effects of the combined treatment Parecoxib (Pcox) and 5,10,15,20-tetra-sulphonato-phenyl-porphyrin(TSPP)-mediated photodynamic therapy on Walker 256 carcinosarcoma.Five groups of male Wistar rats were used: the control group, treat... |
|
|
Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.
J. Clin. Invest. 126 , 695-705, (2016) Systemic inflammation causes malaise and general feelings of discomfort. This fundamental aspect of the sickness response reduces the quality of life for people suffering from chronic inflammatory diseases and is a nuisance during mild infections like common ... |
|
|
A randomized controlled trial of preprocedure administration of parecoxib for therapeutic endoscopic retrograde cholangiopancreatography.
J. Pain Res. 5 , 251-6, (2012) Parecoxib is occasionally used for analgesia in postprocedural patients. The clinical efficacy of parecoxib used for endoscopic retrograde cholangiopancreatography (ERCP) is controversial. The aim of the study was to determine the clinical efficacy of preproc... |
|
|
Fast track liver resection: the effect of a comprehensive care package and analgesia with single dose intrathecal morphine with gabapentin or continuous epidural analgesia.
HPB Surg. 2009 , 271986, (2009) A comprehensive care package for patients undergoing hepatectomy was developed with the aim of minimal physiological disturbance in the peri-operative period. Peri-operative analgesia with few gastrointestinal effects and reduced requirement for intravenous (... |
|
|
Parecoxib is neuroprotective in spontaneously hypertensive rats after transient middle cerebral artery occlusion: a divided treatment response?
J. Neuroinflammation 3 , 31, (2007) Anti-inflammatory treatment affects ischemic damage and neurogenesis in rodent models of cerebral ischemia. We investigated the potential benefit of COX-2 inhibition with parecoxib in spontaneously hypertensive rats (SHRs) subjected to transient middle cerebr... |
|
|
The adverse effect of selective cyclooxygenase-2 inhibitor on random skin flap survival in rats.
PLoS ONE 8 , e82802, (2013) Cyclooxygenase-2(COX-2) inhibitors provide desired analgesic effects after injury or surgery, but evidences suggested they also attenuate wound healing. The study is to investigate the effect of COX-2 inhibitor on random skin flap survival.The McFarlane flap ... |
|
|
Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse.
PLoS ONE 6 , e20062, (2011) Clinical use of selective inhibitors of cyclooxygenase (COX)-2 appears associated with increased risk of thrombotic events. This is often hypothesised to reflect reduction in anti-thrombotic prostanoids, notably PGI(2), formed by COX-2 present within endothel... |
|
|
NSAIDS inhibit in vitro MSC chondrogenesis but not osteogenesis: implications for mechanism of bone formation inhibition in man.
J. Cell. Mol. Med. 15 , 525-34, (2011) The non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for analgesia but may inhibit bone formation. We investigated whether the reported NSAID effect on bone is related to inhibition of bone marrow mesenchymal stem cell (MSC) proliferation and os... |