parecoxib
parecoxib structure
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Common Name | parecoxib | ||
|---|---|---|---|---|
| CAS Number | 198470-84-7 | Molecular Weight | 370.422 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C19H18N2O4S | Melting Point | 148.9-151° | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS08 |
Signal Word | Warning | |
Use of parecoxibParecoxib is a potent and selective COX-2 inhibitor.IC50 value:Target: COX-2in vitro: The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue [1].in vivo: Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days [2]. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision [3]. |
| Name | parecoxib |
|---|---|
| Synonym | More Synonyms |
| Description | Parecoxib is a potent and selective COX-2 inhibitor.IC50 value:Target: COX-2in vitro: The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue [1].in vivo: Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days [2]. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision [3]. |
|---|---|
| Related Catalog | |
| Target |
COX-2 |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Melting Point | 148.9-151° |
| Molecular Formula | C19H18N2O4S |
| Molecular Weight | 370.422 |
| Exact Mass | 370.098724 |
| PSA | 101.14000 |
| LogP | 1.72 |
| Index of Refraction | 1.580 |
| Symbol |
GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H361d-H373 |
| Precautionary Statements | P281 |
| Hazard Codes | Xn,N |
| Risk Phrases | 63-48/22-51/53 |
| Safety Phrases | 36/37-61 |
| RIDADR | NONH for all modes of transport |
| RTECS | TX1478700 |
|
~82%
parecoxib CAS#:198470-84-7 |
| Literature: Talley, John J.; Bertenshaw, Stephen R.; Brown, David L.; Carter, Jeffery S.; Graneto, Matthew J.; Kellogg, Michael S.; Koboldt, Carol M.; Yuan, Jinhua; Zhang, Yan Y.; Seibert, Karen Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1661 - 1663 |
|
~75%
parecoxib CAS#:198470-84-7 |
| Literature: Letendre, Leo J.; Kunda, Sastry A.; Gallagher, Donald J.; Seaney, Lisa M.; McLaughlin, Kathleen Patent: US2003/105334 A1, 2003 ; |
| Precursor 2 | |
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| DownStream 0 | |
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Bsm1 vitamin D receptor polymorphism and calcium homeostasis following bariatric surgery.
J. Invest. Surg. 28(1) , 8-17, (2015) To evaluate the association between the Bsm1 vitamin D receptor polymorphism and the calcium-vitamin D-parathormone axis following bariatric surgery.This cross-sectional study included 86 morbidly obe... |
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The effect of TSPP-mediated photodynamic therapy and Parecoxib in experimental tumours.
Life Sci. 117(2) , 75-83, (2015) The study investigated the effects of the combined treatment Parecoxib (Pcox) and 5,10,15,20-tetra-sulphonato-phenyl-porphyrin(TSPP)-mediated photodynamic therapy on Walker 256 carcinosarcoma.Five gro... |
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Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.
J. Clin. Invest. 126 , 695-705, (2016) Systemic inflammation causes malaise and general feelings of discomfort. This fundamental aspect of the sickness response reduces the quality of life for people suffering from chronic inflammatory dis... |
| N-{[4-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}propanamide |
| N-[[4-[5-methyl-3-phenylisoxazol-4-yl]phenyl]sulfonyl]propanamide |
| parecoxib |
| N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-propanamide |
| 4-[4-(N-propionylsulfamoyl)-phenyl]-5-methyl-3-phenyl-isoxazole |
| N-propanoyl-4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide |
| Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]- |
| N-[[4-[5-methyl-3-phenylisoxazol-4-yl]phenyl]sulfonyl]acetamide |
| Dynastat |
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