Tetracaine hydrochloride
Tetracaine hydrochloride structure
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Common Name | Tetracaine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 136-47-0 | Molecular Weight | 300.824 | |
| Density | N/A | Boiling Point | 389.4ºC at 760 mmHg | |
| Molecular Formula | C15H25ClN2O2 | Melting Point | 149°C | |
| MSDS | Chinese USA | Flash Point | 189.3ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Enhanced regeneration of corneal tissue via a bioengineered collagen construct implanted by a nondisruptive surgical technique.
Tissue Eng. Part A 21(5-6) , 1116-30, (2015) Severe shortage of donor corneas for transplantation, particularly in developing countries, has prompted the advancement of bioengineered tissue alternatives. Bioengineered corneas that can withstand transplantation while maintaining transparency and compatib... |
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Cetacaine induced methemoglobinemia: overview of analysis and treatment strategies.
W. V. Med. J. 109(3) , 24-6, (2013) Methemoglobin is formed upon iron oxidation of the heme molecule from ferrous (Fe2+) to its ferric (Fe3+) state. Normal methemoglobin levels in the body vary between 1-2% of the total hemoglobin. Cause of methemoglobinemia can be inherited or acquired. Inheri... |
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Interaction of local anesthetics with lipid bilayers investigated by ¹H MAS NMR spectroscopy.
Biochim. Biophys. Acta 1818(12) , 3010-8, (2012) The membrane location of the local anesthetics (LA) lidocaine, dibucaine, tetracaine, and procaine hydrochloride as well as their influence on phospholipid bilayers were studied by ³¹P and ¹H magic-angle spinning (MAS) NMR spectroscopy. The ³¹P NMR spectra of... |
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Selective effect of procaine, tetracaine and dibucaine on gold nanoparticles.
J. Nanosci. Nanotechnol. 12(12) , 8935-9, (2012) An aqueous colloid dispersion of gold nanoparticles (AuNPs) was prepared by reduction of gold(III) chloride and its interaction with three local anesthetics (procaine, dibucaine or tetracaine) was investigated. Optical spectra reveal the modifications in the ... |
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Stomatitis Associated With Use of mTOR Inhibitors: Implications for Patients With Invasive Breast Cancer.
Clin. J. Oncol. Nurs. 19 , 468-74, (2015) The mammalian target of rapamycin (mTOR) inhibitor everolimus is approved (in combination with exemestane) for the treatment of postmenopausal women with advanced hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer resis... |
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Contact allergy to local anaesthetics-value of patch testing with a caine mix in the baseline series.
Contact Dermatitis 68(3) , 156-62, (2013) Contact allergy to local anaesthetics is relatively common. Patch testing with benzocaine in the European baseline series is recommended for diagnosis, even though a caine mix has been previously suggested to be superior.To assess the frequency and patterns o... |