MDL 72527
MDL 72527 structure
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Common Name | MDL 72527 | ||
|---|---|---|---|---|
| CAS Number | 93565-01-6 | Molecular Weight | 265.22200 | |
| Density | N/A | Boiling Point | 300.7ºC at 760mmHg | |
| Molecular Formula | C12H22Cl2N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 159.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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How important is the oxidative degradation of spermine?: minireview article.
Amino Acids 26(4) , 317-9, (2004) Spermine is a constituent of most eucaryotic cells, however, it is not of vital importance for the vertebrate organism, as is demonstrated by the existence of transgenic (Gy) mice that lack spermine and spermine synthase. In contrast its degradation appears t... |
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Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells.
Amino Acids 42(2-3) , 619-26, (2012) Polyamines spermidine and spermine are known to be required for mammalian cell proliferation and for embryonic development. Alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC) a limiting enzyme of polyamine biosynthesis, deplet... |
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Synergism between apple procyanidins and lysosomotropic drugs: potential in chemoprevention.
Anticancer Res. 26(5A) , 3381-5, (2006) Procyanidins are apple constituents with potential in colon cancer chemoprevention.Human colon cancer derived metastatic cells (SW620), growing under standardized conditions, were exposed to procyanidins and lysosomotropic compounds. Growth, apoptosis and lys... |
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Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7beta-hydroxycholesterol and 7beta-hydroxysitosterol.
Int. J. Oncol. 29(6) , 1549-54, (2006) 7beta-OHsitosterol and 7beta-OHcholesterol are natural compounds of plant and animal cells with high structural similarity. Recently it was reported that both compounds induced apoptosis on human colon cancer cells by targeting different signalling pathways. ... |
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Cytotoxicity of the polyamine oxidase inactivator MDL 72527 to cancer cells: comparison with a saturated structural analogue.
Int. J. Oncol. 27(6) , 1669-76, (2005) MDL 72527 (N1,N4-di-2,3-butadienyl-1,4-butanediamine) is a selective inactivator of polyamine oxidase with therapeutic potential. However, the development of lethal toxic effects due to prevention of spermine degradation is a considerable disadvantage of the ... |
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MDL 72527 and spermine oxidation products induce a lysosomotropic effect and mitochondrial alterations in tumour cells.
Biochem. Soc. Trans. 35(Pt 2) , 343-8, (2007) Cytotoxic products of polyamines generated in situ by an enzyme-catalysed reaction may be useful as a new avenue in combating cancer. This study demonstrated that MDR (multidrug-resistant) cancer cells (colon adenocarcinoma and melanoma) are significantly mor... |
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Cytotoxic effects of the polyamine oxidase inactivator MDL 72527 to two human colon carcinoma cell lines SW480 and SW620.
Cell Biol. Toxicol. 18(6) , 381-96, (2002) N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL 72527) was considered to be a selective inactivator of FAD-dependent tissue polyamine oxidase. Recently MDL 72527 was reported to induce apoptosis in transformed hematopoietic cells through lysosomotropic effec... |
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Contribution of spermidine to stimulation by hepatocyte growth factor in repair after damage of rabbit gastric mucosal cells in primary culture.
Biochim. Biophys. Acta 1619(2) , 187-92, (2003) Wound-healing of the gastric mucosa is suggested to be stimulated by hepatocyte growth factor (HGF). Polyamines are shown to contribute to repair after damage in the gastric mucosa. The present study was designed to elucidate whether HGF can stimulate wound-h... |
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Inhibition of murine N1-acetylated polyamine oxidase by an acetylenic amine and the allenic amine, MDL 72527.
Biochem. Biophys. Res. Commun. 326(2) , 483-90, (2005) Murine N(1)-acetylated polyamine oxidase (mPAO) was treated with N,N'-bis-(prop-2-ynyl)-1,4-diaminobutane, a poor substrate and inhibitor for the enzyme, with K(m) and K(i) values in the millimolar range. Apparently, its oxidation produces prop-2-ynal, which ... |
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Interaction of bovine serum amine oxidase with the polyamine oxidase inactivator MDL 72527.
Biochem. Biophys. Res. Commun. 340(3) , 840-4, (2006) MDL 72527 was considered a selective inhibitor of FAD-dependent polyamine oxidases. In the present communication, we demonstrate that MDL 72527 inactivates bovine serum amine oxidase, a copper-containing, TPQ-enzyme, time-dependently at 25 degrees C. In strik... |