MDL 72527
Modify Date: 2024-01-05 10:13:11
MDL 72527 structure
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Common Name | MDL 72527 | ||
|---|---|---|---|---|
| CAS Number | 93565-01-6 | Molecular Weight | 265.22200 | |
| Density | N/A | Boiling Point | 300.7ºC at 760mmHg | |
| Molecular Formula | C12H22Cl2N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 159.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of MDL 72527MDL 72527 dihydrochloride is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 dihydrochloride shows a lysosomotropic effect. MDL 72527 dihydrochloride shows neuroprotective effects[1][2]. |
| Name | N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | MDL 72527 dihydrochloride is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 dihydrochloride shows a lysosomotropic effect. MDL 72527 dihydrochloride shows neuroprotective effects[1][2]. |
|---|---|
| Related Catalog | |
| Target |
polyamine oxidase (PAO)[1] |
| In Vitro | MDL 72527 dihydrochloride (300 µM; 24 h) 在 M14 WT 细胞中出现明显的形态学变化，出现大量溶酶体和大量细胞质空泡[2]。 Cell Cytotoxicity Assay[2] Cell Line: M14 cells Concentration: 300 µM Incubation Time: 24 h Result: Showed no significant effect on cell survival of melanoma cells. |
| In Vivo | MDL 72527 dihydrochloride (100 mg/kg; i.p.; once) 对暂时性局灶性脑缺血后的神经元细胞损伤具有神经保护作用[1]。 Animal Model: 250-300 g, Male spontaneously hypertensive rats (SHRs)[1] Dosage: 100 mg/kg Administration: I.p.; after the induction of ischemia Result: Significantly reduced meanarterial blood pressure, changed the brain edema formation from 85.7 ± 0.3 to 84.5 ± 0.9% in cortex and from 79.9 ± 1.7 to 78.4 ± 2.0% in subcortex (difference not significant), reduced ischemic injury volume by 22% in the cortex and 17% in the subcortex. |
| References |
| Boiling Point | 300.7ºC at 760mmHg |
|---|---|
| Molecular Formula | C12H22Cl2N2 |
| Molecular Weight | 265.22200 |
| Flash Point | 159.2ºC |
| Exact Mass | 264.11600 |
| PSA | 24.06000 |
| LogP | 4.01380 |
| Index of Refraction | 1.536 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2921290000 |
| HS Code | 2921290000 |
|---|---|
| Summary | 2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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| N,N'-bis(buta-2,3-dienyl)butane-1,4-diamine,dihydrochloride |