93565-01-6

93565-01-6 structure

Name: MDL 72527
Chemical Name: N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride
CAS Number: 93565-01-6
Molecular Formula: C₁₂H₂₂Cl₂N₂
Molecular Weight: 265.22200
Catalog: Research Areas Neurological Disease
Create Date: 2018-12-04 18:18:37
Modify Date: 2024-01-05 10:13:11
MDL 72527 dihydrochloride is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 dihydrochloride shows a lysosomotropic effect. MDL 72527 dihydrochloride shows neuroprotective effects[1][2].

Name	N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride
Synonyms	N,N'-bis(buta-2,3-dienyl)butane-1,4-diamine,dihydrochloride

Description	MDL 72527 dihydrochloride is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 dihydrochloride shows a lysosomotropic effect. MDL 72527 dihydrochloride shows neuroprotective effects[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	polyamine oxidase (PAO)[1]
In Vitro	MDL 72527 dihydrochloride (300 µM; 24 h) 在 M14 WT 细胞中出现明显的形态学变化，出现大量溶酶体和大量细胞质空泡[2]。 Cell Cytotoxicity Assay[2] Cell Line: M14 cells Concentration: 300 µM Incubation Time: 24 h Result: Showed no significant effect on cell survival of melanoma cells.
In Vivo	MDL 72527 dihydrochloride (100 mg/kg; i.p.; once) 对暂时性局灶性脑缺血后的神经元细胞损伤具有神经保护作用[1]。 Animal Model: 250-300 g, Male spontaneously hypertensive rats (SHRs)[1] Dosage: 100 mg/kg Administration: I.p.; after the induction of ischemia Result: Significantly reduced meanarterial blood pressure, changed the brain edema formation from 85.7 ± 0.3 to 84.5 ± 0.9% in cortex and from 79.9 ± 1.7 to 78.4 ± 2.0% in subcortex (difference not significant), reduced ischemic injury volume by 22% in the cortex and 17% in the subcortex.
References	[1]. Doğan A, et al. Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J Neurochem. 1999 Feb;72(2):765-70. [2]. Agostinelli E, et al. Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. Biochim Biophys Acta. 2006 Oct;1763(10):1040-50.

Boiling Point	300.7ºC at 760mmHg
Molecular Formula	C₁₂H₂₂Cl₂N₂
Molecular Weight	265.22200
Flash Point	159.2ºC
Exact Mass	264.11600
PSA	24.06000
LogP	4.01380
Index of Refraction	1.536
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
RIDADR	NONH for all modes of transport
HS Code	2921290000

HS Code	2921290000
Summary	2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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