107703-78-6

107703-78-6 structure

Name: MDL 11,939
Chemical Name: MDL 11,939,α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol
CAS Number: 107703-78-6
Molecular Formula: C₂₀H₂₅NO
Molecular Weight: 295.41900
Create Date: 2017-10-08 10:35:48
Modify Date: 2025-08-24 22:25:19
Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively)[1][2].

Name	MDL 11,939,α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol
Synonyms	laminaritriose Glemanserin

Description	Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively)[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter
In Vivo	Glemanserin (MDL11939) suppresses Morphine-induced increase in locomotor activity, behavioral sensitization and withdrawal symptoms in male mice[1].
References	[1]. Pehek EA, et al. Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Neuropsychopharmacology. 2006;31(2):265-277.