BAPTA-AM
BAPTA-AM structure
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Common Name | BAPTA-AM | ||
|---|---|---|---|---|
| CAS Number | 126150-97-8 | Molecular Weight | 764.684 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 796.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C34H40N2O18 | Melting Point | 86-90°C | |
| MSDS | Chinese USA | Flash Point | 435.3±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns.
Cell Death Dis. 5 , e1494, (2014) Apoptosis, which is anti-inflammatory, and necrosis, which is pro-inflammatory, represent the extremes of the cell death spectrum. Cell death is complex and both apoptosis and necrosis can be observed in the same cells or tissues. Here, we introduce a novel c... |
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Kinetics of human sperm acrosomal exocytosis.
Mol. Hum. Reprod. 21(3) , 244-54, (2015) The acrosome reaction is a unique event in the lifespan of sperm characterized by the exocytosis of the acrosomal content and the release of hybrid vesicles formed by patches of the outer acrosomal membrane and the plasma membrane. This unique regulated exocy... |
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Mechanosensitive store-operated calcium entry regulates the formation of cell polarity.
J. Cell Physiol. 230 , 2086-97, (2015) Ca(2+) -mediated formation of cell polarity is essential for directional migration which plays an important role in physiological and pathological processes in organisms. To examine the critical role of store-operated Ca(2+) entry, which is the major form of ... |
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Ozone (O3) elicits neurotoxicity in spinal cord neurons (SCNs) by inducing ER Ca(2+) release and activating the CaMKII/MAPK signaling pathway.
Toxicol. Appl. Pharmacol. 280(3) , 493-501, (2014) Ozone (O3) is widely used in the treatment of spinal cord related diseases. Excess or accumulation of this photochemical air can however be neurotoxic. In this study, in vitro cultured Wister rat spinal cord neurons (SCNs) were used to investigate the detrime... |
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Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress.
Chem. Biol. Interact. 218 , 28-41, (2014) Malignant gliomas are the most common primary brain tumors, and novel ways of treating gliomas are urgently needed. Ursolic acid (UA), a pentacyclic triterpenoid, has been reported to exhibit promising antitumor activity. Here, we evaluated the effects of UA ... |
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Exopolysaccharide of Antarctic bacterium Pseudoaltermonas sp. S-5 induces apoptosis in K562 cells.
Carbohydr. Polym. 121 , 107-14, (2015) The aim of this study was to investigate the anticancer activity of exopolysaccharide (PEP) of Antarctic bacterium Pseudoaltermonas sp. S-5 and elucidate the underlying molecular mechanisms. PEP significantly inhibited the growth of human leukemia K562 cells.... |
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Astrocyte VAMP3 vesicles undergo Ca2+ -independent cycling and modulate glutamate transporter trafficking.
J. Physiol. 593 , 2807-32, (2015) Mouse cortical astrocytes express VAMP3 but not VAMP2. VAMP3 vesicles undergo Ca(2+) -independent exo- and endocytotic cycling at the plasma membrane. VAMP3 vesicle traffic regulates the recycling of plasma membrane glutamate transporters. cAMP modulates VAMP... |
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Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK.
Toxicol. Appl. Pharmacol. 286 , 53-63, (2015) Curcumin is a natural polyphenolic compound in Curcuma longa with beneficial effects on neuronal protection. This study aims to investigate the action of curcumin in the hippocampus subjected to glutamate neurotoxicity. Glutamate stimulation induced reactive ... |
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Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy.
Cardiovasc. Res. 105(1) , 55-64, (2014) Stimulation of β-adrenergic receptors (β-AR) increases cAMP production and contributes to the pathogenesis of cardiac hypertrophy and failure through poorly understood mechanisms. We previously demonstrated that Exchange protein directly activated by cAMP 1 (... |
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Fibronectin enhances spinal cord astrocyte proliferation by elevating P2Y1 receptor expression.
J. Neurosci. Res. 92(8) , 1078-90, (2014) After spinal cord injury (SCI), the formation of glial scar is a complex process that is attributed primarily to astrocytic proliferation, but the mechanism of astrocytes proliferation is still unclear. Fibronectin is a large extracellular glycoprotein that h... |