2-Thiouracil
2-Thiouracil structure
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Common Name | 2-Thiouracil | ||
|---|---|---|---|---|
| CAS Number | 141-90-2 | Molecular Weight | 128.152 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 337.2ºC at 760mmHg | |
| Molecular Formula | C4H4N2OS | Melting Point | >300 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 157.7ºC | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
J. Med. Chem. 54 , 591-602, (2011) Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix metallop... |
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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
J. Med. Chem. 51 , 6740-51, (2008) The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives, and the theoretical pr... |
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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Toxicol. Mech. Methods 18 , 217-27, (2008) ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the dev... |
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Validation of a streamlined multiclass, multiresidue method for determination of veterinary drug residues in bovine muscle by liquid chromatography-tandem mass spectrometry.
Anal. Bioanal. Chem 407 , 4423-35, (2015) Multiclass, multiresidue methods are becoming increasingly popular in regulatory monitoring programs due to their increased analytical scope and laboratory efficiency. In this work, we report the development and validation of a new high-throughput analytical ... |
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Photoelectron spectroscopic study of the negative ions of 4-thiouracil and 2,4-dithiouracil.
J. Chem. Phys. 134(7) , 074304, (2011) We report the photoelectron spectra of the negative ions of 4-thiouracil (4-TU)(-) and 2,4-dithiouracil (2,4-DTU)(-). Both of these spectra are indicative of valence anions, and they are each dominated by a single broad band with vertical detachment energies ... |
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Mechanism and dynamics of intramolecular triplet state decay of 1-propyl-4-thiouracil and its α-methyl-substituted derivatives studied in perfluoro-1,3-dimethylcyclohexane.
Photochem. Photobiol. Sci. 10(8) , 1294-302, (2011) Zinc deficiency is causing malnutrition for nearly one third of world populations. It is especially relevant in cereal-based diets in which low amounts of mineral and protein are present. In biological systems, Zn is mainly associated with protein. Cereal gra... |
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Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs.
J. Biol. Chem. 288(41) , 29954-64, (2013) The pathogenic protozoan parasite Leishmania donovani is capable of both de novo pyrimidine biosynthesis and salvage of pyrimidines from the host milieu. Genetic analysis has authenticated L. donovani uracil phosphoribosyltransferase (LdUPRT), an enzyme not f... |
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Thiouracil cross-linking mass spectrometry: a cell-based method to identify host factors involved in viral amplification.
J. Virol. 87(15) , 8697-712, (2013) Eukaryotic RNA viruses are known to utilize host factors; however, the identity of these factors and their role in the virus life cycle remain largely undefined. Here, we report a method to identify proteins bound to the viral RNA during amplification in cell... |
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Hydration energies of protonated and sodiated thiouracils.
J. Am. Soc. Mass Spectrom. 25(12) , 2134-42, (2014) Hydration reactions of protonated and sodiated thiouracils (2-thiouracil, 6-methyl-2-thiouracil, and 4-thiouracil) generated by electrospray ionization have been studied in a gas phase at 10 mbar using a pulsed ion-beam high-pressure mass spectrometer. The th... |
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Dynamic profiling of mRNA turnover reveals gene-specific and system-wide regulation of mRNA decay.
Mol. Biol. Cell 22(15) , 2787-95, (2011) RNA levels are determined by the rates of both transcription and decay, and a mechanistic understanding of the complex networks regulating gene expression requires methods that allow dynamic measurements of transcription and decay in living cells with minimal... |