Cephalomannine
Cephalomannine structure
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Common Name | Cephalomannine | ||
|---|---|---|---|---|
| CAS Number | 71610-00-9 | Molecular Weight | 831.901 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 929.5±65.0 °C at 760 mmHg | |
| Molecular Formula | C45H53NO14 | Melting Point | 139-141ºC | |
| MSDS | Chinese USA | Flash Point | 516.0±34.3 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Determination of paclitaxel and related taxanes in bulk drug and injectable dosage forms by reversed phase liquid chromatography.
Anal. Chem. 69(11) , 2008-16, (1997) Baseline separation of 15 taxanes including paclitaxel (Taxol) was achieved on pentafluorophenyl (PFP) HPLC columns. Methods using aqueous acetonitrile gradients on each of two commercial PFP columns were developed that are suitable for the determination of p... |
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Determination of cephalomannine in rat plasma by gradient elution UPLC-MS/MS method.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 963 , 70-4, (2014) A rapid, sensitive and selective ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed and validated for the determination and pharmacokinetic investigation of cephalomannine in rat plasma. Sample preparation was accompli... |
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Microbial transformation of cephalomannine by Luteibacter sp.
J. Nat. Prod. 70(12) , 1846-9, (2007) Luteibacter sp., a new bacterium isolated from the soil around a Taxus cuspidata Sieb. et Zucc plant, was studied for its capability to metabolize cephalomannine (1). After preparative fermentation, eight metabolites were obtained and characterized as baccati... |
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Seasonal changes in the concentrations of four taxoids in Taxus baccata L. during the autumn-spring period.
Phytomedicine 6(2) , 135-40, (1999) The concentrations of four common taxoids: baccatin III, paclitaxel, cephalomannine and 10-deacetylbaccatin III (10-DAB III) were measured in fresh needles and stems of Taxus baccata L. during the late autumn-spring period (November'96-April'97) which has not... |
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Rapid separation of four main taxoids in Taxus species by a combined LLP-SPE-HPLC (PAD) procedure.
J. Sep. Sci. 29(9) , 1237-44, (2006) A method is described for the simultaneous determination of paclitaxel and three related taxoids, 10-deacetylbaccatin III (10-DAB III), baccatin III, and cephalomannine, in the extracts from the needles of three Chinese yew species, Taxus cuspidata, T. chinen... |
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Development of a fluorescence immunoassay for measurement of paclitaxel in human plasma.
Anal. Biochem. 283(1) , 33-8, (2000) A new fluorescence immunoassay for the quantitative determination of paclitaxel (Pac) under equilibrium conditions was developed. Anti-Pac IgG2a antibody was immobilized through its Fc region to protein A covalently bound to the inside surface of a silanized ... |
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Overcoming tumor drug resistance with C2-modified 10-deacetyl-7-propionyl cephalomannines: a QSAR study.
Mol. Pharm. 6(3) , 849-60, (2009) The microtubule-stabilizing taxanes such as paclitaxel and docetaxel are the two most important anticancer drugs currently used in clinics for the treatment of various types of cancers. However, the major common drawbacks of these two drugs are drug resistanc... |
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Identification of isocephalomannine in the presence of cephalomannine isomers and alkali metal ion adducts in a paclitaxel active pharmaceutical ingredient using electrospray tandem mass spectrometry.
Rapid Commun. Mass Spectrom. 20(11) , 1731-5, (2006) A strategy is developed for the identification of isocephalomannine in the presence of alkali metal ion adducts and other cephalomannine isomers in a paclitaxel active pharmaceutical ingredient. Intact molecular ion analyses and a sub-structural study have be... |
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A novel bioassay for screening and quantification of taxanes.
Chem. Commun. (Camb.) (10) , 1188-9, (2003) We report a novel method for screening and quantifying tubulin-binding antimitotic agents that promote microtubule formation. The method is based on the shift in the peak of the fluorescence emission difference spectrum of tubulin complexed to metal free tetr... |
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Synthesis and biological activities of high affinity taxane-based fluorescent probes
Bioorg. Med. Chem. Lett. 19(3) , 751-4, (2009) Three fluorescent probes 3a, 3b, and 4 have been synthesized through conjugation of fluorescein and difluorescein groups to the 7-OH of C-2 modified paclitaxel and cephalomannine derivatives with very high affinity to microtubules. All these probes exhibited ... |