Cephalomannine

Modify Date: 2024-01-02 06:27:32

Cephalomannine structure	Common Name	Cephalomannine
	CAS Number	71610-00-9	Molecular Weight	831.901
	Density	1.4±0.1 g/cm3	Boiling Point	929.5±65.0 °C at 760 mmHg
	Molecular Formula	C₄₅H₅₃NO₁₄	Melting Point	139-141ºC
	MSDS	Chinese USA	Flash Point	516.0±34.3 °C
	Symbol	GHS05, GHS07	Signal Word	Danger

Use of Cephalomannine

Cephalomannine is a taxol derivative with antitumor, antiproliferative properties. IC50 value:Target: Cephalomannine is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice. Cephalomannine is a chemotherapy drug that is given as a treatment for some types of cancer. Cephalomannine is most commonly used to treat non-small cell lung cancer.

Name	Cephalomannine
Synonym	More Synonyms

Description	Cephalomannine is a taxol derivative with antitumor, antiproliferative properties. IC50 value:Target: Cephalomannine is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice. Cephalomannine is a chemotherapy drug that is given as a treatment for some types of cancer. Cephalomannine is most commonly used to treat non-small cell lung cancer.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer
References	[1]. T. Grobosch, B. Schwarze, D. Stoecklein et al. Fatal poisoning with Taxus baccata. Quantification of Paclitaxel (taxol A), 10-Deacetyltaxol, Baccatin III, 10-Deacetylbaccatin III, Cephalomannine (taxol B), and 3,5-Dimethoxyphenol in Body Fluids by Liquid [2]. Jing Zhang et al., Simultaneous Determination of 10-Deacetylbaccatin，Cephalomannine and Taxol in Different Parts of Taxus Media with Different Growth Years by UPLC. Applied Mechanics and Materials. 2011, 108, 326. [3]. Chang Z, Guo N, Liu T, et al. Distribution and variation of paclitaxel and cephalomannine contents in wild Taxus cuspidata. Zhongguo Zhong Yao Za Zhi. 2011 Feb;36(3):294-8. [4]. R Matesanz, J Rodríguez-Salarichs, B Pera, et al. Modulation of Microtubule Interprotofilament Interactions by Modified Taxanes. Biophysical Journal, 2011,101(12): 2970-2980. [5]. Elena Riva, Martin Mattarella, Stella Borrelli, et al. Preparation of Fluorescent Tubulin Binders. ChemPlusChem. Early View (Online Version of Record published before inclusion in an issue)

Description

Related Catalog

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

Natural Products >> Terpenoids and Glycosides

Research Areas >> Cancer

References

[1]. T. Grobosch, B. Schwarze, D. Stoecklein et al. Fatal poisoning with Taxus baccata. Quantification of Paclitaxel (taxol A), 10-Deacetyltaxol, Baccatin III, 10-Deacetylbaccatin III, Cephalomannine (taxol B), and 3,5-Dimethoxyphenol in Body Fluids by Liquid

[2]. Jing Zhang et al., Simultaneous Determination of 10-Deacetylbaccatin，Cephalomannine and Taxol in Different Parts of Taxus Media with Different Growth Years by UPLC. Applied Mechanics and Materials. 2011, 108, 326.

[3]. Chang Z, Guo N, Liu T, et al. Distribution and variation of paclitaxel and cephalomannine contents in wild Taxus cuspidata. Zhongguo Zhong Yao Za Zhi. 2011 Feb;36(3):294-8.

[4]. R Matesanz, J Rodríguez-Salarichs, B Pera, et al. Modulation of Microtubule Interprotofilament Interactions by Modified Taxanes. Biophysical Journal, 2011,101(12): 2970-2980.

[5]. Elena Riva, Martin Mattarella, Stella Borrelli, et al. Preparation of Fluorescent Tubulin Binders. ChemPlusChem. Early View (Online Version of Record published before inclusion in an issue)

Density	1.4±0.1 g/cm3
Boiling Point	929.5±65.0 °C at 760 mmHg
Melting Point	139-141ºC
Molecular Formula	C₄₅H₅₃NO₁₄
Molecular Weight	831.901
Flash Point	516.0±34.3 °C
Exact Mass	831.346619
PSA	221.29000
LogP	6.59
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.615
Storage condition	-20°C Freezer
Water Solubility	DMSO: 14 mg/mL, soluble

Cephalomannine MSDS(Chinese)

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	37/38-41
Safety Phrases	26-39
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2932999022

2'-acetylcephal...

CAS#:861856-91-9

Cephalomannine

CAS#:71610-00-9

Literature: US2008/287696 A1, ; Page/Page column 6 ;

N/A

CAS#:502626-21-3

Cephalomannine

CAS#:71610-00-9

Literature: Roh, Eun Joo; Kim, Deukjoon; Lee, Chong Ock; Choi, Sang Un; Song, Choong Eui Bioorganic and medicinal chemistry, 2002 , vol. 10, # 10 p. 3145 - 3151

N/A

CAS#:261728-77-2

Cephalomannine

CAS#:71610-00-9

Literature: Bioorganic and medicinal chemistry, , vol. 10, # 10 p. 3145 - 3151

CAS#:204125-01-9

Cephalomannine

CAS#:71610-00-9

Literature: Bioorganic and medicinal chemistry, , vol. 10, # 10 p. 3145 - 3151

7-trichloroacet...

CAS#:204124-97-0

Cephalomannine

CAS#:71610-00-9

Literature: Bioorganic and medicinal chemistry, , vol. 10, # 10 p. 3145 - 3151

Precursor 2
CAS#:861856-91-9 2'-acetylcephal... CAS#:204124-97-0 7-trichloroacet...
DownStream 8
CAS#:32981-86-5 10-Deacetylbacc... CAS#:71610-01-0 methyl (Z)-2-hy... CAS#:27548-93-2 Baccatin III CAS#:76480-33-6 (1Z,3E,9Z)-1-Ch...
CAS#:76429-85-1 10-Deacetylceph... CAS#:71629-92-0 10-Deacetyl CAS#:33069-62-4 Paclitaxel CAS#:133524-70-6 3'-N-debenzoyltaxol

HS Code	2932999022

Determination of paclitaxel and related taxanes in bulk drug and injectable dosage forms by reversed phase liquid chromatography.

Anal. Chem. 69(11) , 2008-16, (1997)

Baseline separation of 15 taxanes including paclitaxel (Taxol) was achieved on pentafluorophenyl (PFP) HPLC columns. Methods using aqueous acetonitrile gradients on each of two commercial PFP columns ...

Determination of cephalomannine in rat plasma by gradient elution UPLC-MS/MS method.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 963 , 70-4, (2014)

A rapid, sensitive and selective ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed and validated for the determination and pharmacokinetic investigation of ce...

Microbial transformation of cephalomannine by Luteibacter sp.

J. Nat. Prod. 70(12) , 1846-9, (2007)

Luteibacter sp., a new bacterium isolated from the soil around a Taxus cuspidata Sieb. et Zucc plant, was studied for its capability to metabolize cephalomannine (1). After preparative fermentation, e...

Paclitaxel Related CoMpound A

(2α,5β,7β,10β,13α)-4,10-Diacetoxy-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methylbut-2-enoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecah ydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

chephalomannine

(2α,5β,7β,10β,13α)-4,10-Diacetoxy-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methyl-2-butenoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

3'-N-(trans-2-methyl-2-butenoyl)-3'-N-debenzoylpaclitaxel

CEPHALOMANNINE:BENZENEPROPANOICACID,-HYDROXY--[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OX...

caphalomannine

Paclitaxel Related Compound A (20 mg) (Ce-phalomannine)

(2α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methylbut-2-enoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

TAXOL B

CEPHALOMANNINE (TAXOL B)

CEPHALOMANNINE(P)

BioBioPha
China
Product Name: Cephalomannine
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Cephalomannine
Price: ￥398.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Cephalomannine
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Cephalomannine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $242/10mM*1mLinDMSO

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Cephalomannine

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