10-Deacetylbaccatin III
Modify Date: 2024-01-02 10:11:07
10-Deacetylbaccatin III structure
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Common Name | 10-Deacetylbaccatin III | ||
|---|---|---|---|---|
| CAS Number | 32981-86-5 | Molecular Weight | 544.590 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 716.8±60.0 °C at 760 mmHg | |
| Molecular Formula | C29H36O10 | Melting Point | 231-236 °C | |
| MSDS | Chinese USA | Flash Point | 233.5±26.4 °C | |
Use of 10-Deacetylbaccatin III10-Deacetylbaccatin-III is an intermediate for taxol analog preparations. IC50 value:Target: Taxols have exhibit antitumor agents. Several of these taxols can be synthesized from 10- Deacetylbaccatin-III. 10-Deacetylbaccine III is the fifth intermediate of paclitaxel biosynthesis. The biosynthetic pathway consists of approximately 20 enzymatic steps but is not fully elucidated. 10-Deacetylbaccine III is an antineoplastic agent and an anti-cancer intermediate. |
| Name | 10-deacetylbaccatin III |
|---|---|
| Synonym | More Synonyms |
| Description | 10-Deacetylbaccatin-III is an intermediate for taxol analog preparations. IC50 value:Target: Taxols have exhibit antitumor agents. Several of these taxols can be synthesized from 10- Deacetylbaccatin-III. 10-Deacetylbaccine III is the fifth intermediate of paclitaxel biosynthesis. The biosynthetic pathway consists of approximately 20 enzymatic steps but is not fully elucidated. 10-Deacetylbaccine III is an antineoplastic agent and an anti-cancer intermediate. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 716.8±60.0 °C at 760 mmHg |
| Melting Point | 231-236 °C |
| Molecular Formula | C29H36O10 |
| Molecular Weight | 544.590 |
| Flash Point | 233.5±26.4 °C |
| Exact Mass | 544.230835 |
| PSA | 159.82000 |
| LogP | 3.51 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.624 |
| Water Solubility | INSOLUBLE |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | T:Toxic |
| Risk Phrases | R23/24/25 |
| Safety Phrases | S45-S38-S36/37/39-S28A |
| RIDADR | 1544 |
| WGK Germany | 3 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| Precursor 7 | |
|---|---|
| DownStream 10 | |
CAS#:115437-18-8
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CAS#:78432-77-6![(3aS,5S,7aS,10aS,11S,12R,12aS)-6,9,9,11,13,13-hexamethyl-2-oxo-5-((triisopropylsilyl)oxy)-5,7a,10a,11,12,12a-hexahydro-4H-3a,7-methanocyclodeca[1,2-d:5,6-d']bis([1,3]dioxole)-12-carbaldehyde Structure](https://www.chemsrc.com/caspic/032/187960-83-4.png)
CAS#:187960-83-4![2-((3aS,5S,8S,9S,10S,11R,11aS)-8,9-dihydroxy-6,10,12,12-tetramethyl-2-oxo-5-((triisopropylsilyl)oxy)-5,8,9,10,11,11a-hexahydro-4H-3a,7-methanocyclodeca[d][1,3]dioxol-11-yl)acetaldehyde Structure](https://www.chemsrc.com/caspic/456/187960-85-6.png)
CAS#:187960-85-6![13-{[(3-t-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(2,2,2-trichloroethyl)oxy]carbonyl) Baccatin III structure](https://www.chemsrc.com/caspic/107/143527-73-5.png)
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CAS#:133524-70-6![7,10-Bis[O-(triethylsilyl)]-10-deacetyl Baccatin III structure](https://www.chemsrc.com/caspic/360/149107-84-6.png)
CAS#:149107-84-6
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CAS#:156294-36-9|
Disposition of [G-(3)H]paclitaxel and cremophor EL in a patient with severely impaired renal function.
Drug Metab. Dispos. 27 , 1300, (1999) In the present work, we studied the pharmacokinetics and metabolic disposition of [G-(3)H]paclitaxel in a female patient with recurrent ovarian cancer and severe renal impairment (creatinine clearance... |
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Molecular mechanisms of patupilone resistance.
Cancer Res. 68 , 10197-10204, (2008) Patupilone is an epothilone in advanced clinical development that has shown promising efficacy in heavily pretreated patients. This study aimed at characterizing the mechanisms of patupilone activity ... |
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Taxol biosynthesis: Molecular cloning of a benzoyl- CoA:taxane 2-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli Kevin Walker and Rodney Croteau PNAS
Proc. 10th Am. Peptide Symp 97 , 13591-13596, (2000)
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| 10-Dab |
| 10-DAB (10-Deacetylbaccatin) |
| MFCD00132913 |
| EINECS 418-680-6 |
| (2α,5β,7β,10α,13α)-4-Acetoxy-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate |
| (2α,5β,7β,10β,13α)-4-(acetyloxy)-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate |
| 10-Deacetylbaccatine |
| 10-deacetylbaccatin11 |
| 10-DAB-III |
| 10DBA III |
| 10-Deacetyl |
| 10-DEACETYLBACCATIN |
| 10-Deacetylbaccatin-III |
| 10-desacetylbaccatin III |
| 10-Deacetylbaccatin III |
| DESACETYLBACCATINE |
| Docetaxel impurity E |
| 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6S,9S,11S,12S,12aR,12bS)- |
| (2α,5β,7β,10β,13α)-4-Acetoxy-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate |
| 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)- |
- BioBioPha
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- Product Name: 10-Deacetylbaccatin III
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- Purity: 98.0%
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- Purity: 99.0%
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- Contact: Anson
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