Larotaxel

Modify Date: 2024-01-12 18:19:57

Larotaxel structure	Common Name	Larotaxel
	CAS Number	156294-36-9	Molecular Weight	831.901
	Density	1.4±0.1 g/cm3	Boiling Point	889.3±65.0 °C at 760 mmHg
	Molecular Formula	C₄₅H₅₃NO₁₄	Melting Point	N/A
	MSDS	N/A	Flash Point	491.7±34.3 °C

Use of Larotaxel

Larotaxel (XRP9881) is a taxane analogue with preclinical activity against taxane-resistant breast cancer. Larotaxel (XRP9881) exerts its cytotoxic effect by promoting tubulin assembly and stabilizing microtubules, ultimately leading to cell death by apoptosis. It presents the ability to cross the blood brain barrier and has a much lower affinity for P-glycoprotein 1 than Docetaxel[1][2][3].

Name	(3ξ,5β,7β,10β)-4,10-Diacetoxy-1-hydroxy-13-{[(3S)-2-hydroxy-3-({[ (2-methyl-2-propanyl)oxy]carbonyl}amino)-3-phenylpropanoyl]oxy}-9 -oxo-5,20-epoxy-7,19-cyclotax-11-en-2-yl benzoate
Synonym	More Synonyms

Description	Larotaxel (XRP9881) is a taxane analogue with preclinical activity against taxane-resistant breast cancer. Larotaxel (XRP9881) exerts its cytotoxic effect by promoting tubulin assembly and stabilizing microtubules, ultimately leading to cell death by apoptosis. It presents the ability to cross the blood brain barrier and has a much lower affinity for P-glycoprotein 1 than Docetaxel[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Diéras V, et al. Phase II multicenter study of larotaxel (XRP9881), a novel taxoid, in patients with metastatic breast cancer who previously received taxane-based therapy. Ann Oncol. 2008 Jul;19(7):1255-60. [2]. Morris PG, et al. Novel anti-tubulin cytotoxic agents for breast cancer. Expert Rev Anticancer Ther. 2009 Feb;9(2):175-85. [3]. Zatloukal P, et al. Randomized multicenter phase II study of larotaxel (XRP9881) in combination with cisplatin or gemcitabine as first-line chemotherapy in nonirradiable stage IIIB or stage IV non-small cell lung cancer. J Thorac Oncol. 2008 Aug;3(8):894-901.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

References

[1]. Diéras V, et al. Phase II multicenter study of larotaxel (XRP9881), a novel taxoid, in patients with metastatic breast cancer who previously received taxane-based therapy. Ann Oncol. 2008 Jul;19(7):1255-60.

[2]. Morris PG, et al. Novel anti-tubulin cytotoxic agents for breast cancer. Expert Rev Anticancer Ther. 2009 Feb;9(2):175-85.

[3]. Zatloukal P, et al. Randomized multicenter phase II study of larotaxel (XRP9881) in combination with cisplatin or gemcitabine as first-line chemotherapy in nonirradiable stage IIIB or stage IV non-small cell lung cancer. J Thorac Oncol. 2008 Aug;3(8):894-901.

Density	1.4±0.1 g/cm3
Boiling Point	889.3±65.0 °C at 760 mmHg
Molecular Formula	C₄₅H₅₃NO₁₄
Molecular Weight	831.901
Flash Point	491.7±34.3 °C
Exact Mass	831.346619
PSA	213.78000
LogP	7.06
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.613

(2α,3α,4α,5β,7α...

CAS#:156294-35-8

Larotaxel

CAS#:156294-36-9

Literature: US2012/149925 A1, ; Page/Page column 17 ;

10-Deacetylbacc...

CAS#:32981-86-5

Larotaxel

CAS#:156294-36-9

Literature: US2012/149925 A1, ;

Baccatin III

CAS#:27548-93-2

Larotaxel

CAS#:156294-36-9

Literature: US2012/149925 A1, ;

(2α,3α,4α,5β,7α...

CAS#:156294-33-6

Larotaxel

CAS#:156294-36-9

Literature: US2012/149925 A1, ;

Precursor 3
CAS#:156294-35-8 (2α,3α,4α,5β,7α... CAS#:32981-86-5 10-Deacetylbacc... CAS#:27548-93-2 Baccatin III
DownStream 0

acetylcyclopropyl docetaxel

Valiolamine hydrate

Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (1S,2S,4S,7R,8aR,9aS,10aR,12aS,12bR)-7,12a-bis(acetyloxy)-1-(benzoyloxy)-1,3,4,7,8,9,9a,10,10a,12,12a,12b-dodecahydro- 2-hydroxy-5,13,13-trimethyl-8-oxo-2,6-methano-2H-cyclodeca[3,4]cyclopropa[4,5]benz[1,2-b]oxet-4-yl ester, (αR,βS)-

Valinolamine

valiolamine

acetocyclopropyl taxotere

(2α,5β,7β,10β,13α)-4,10-Diacetoxy-1-hydroxy-13-{[(2R,3S)-2-hydroxy-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxy-7,19-cyclotax-11-en-2-yl benzo 
ate

Larotaxel

Use of Larotaxel

Names

Larotaxel Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms