Deacetyltaxol

Modify Date: 2024-01-02 10:55:46

Deacetyltaxol structure	Common Name	Deacetyltaxol
	CAS Number	78432-77-6	Molecular Weight	811.870
	Density	1.4±0.1 g/cm3	Boiling Point	959.5±65.0 °C at 760 mmHg
	Molecular Formula	C₄₅H₄₉NO₁₃	Melting Point	182-184ºC
	MSDS	N/A	Flash Point	534.1±34.3 °C

Use of Deacetyltaxol

10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc[1]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro[2]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines[3].

Name	Deacetyltaxol
Synonym	More Synonyms

Description	10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc[1]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro[2]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines[3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	tubulin[2]
References	[1]. 19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana. J Nat Prod. 1981 May-Jun;44(3):312-9. [2]. Michel Colin, et al. Process for the preparation of taxol and 10-deacetyltaxol. US4857653A. [3]. Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9.

Density	1.4±0.1 g/cm3
Boiling Point	959.5±65.0 °C at 760 mmHg
Melting Point	182-184ºC
Molecular Formula	C₄₅H₄₉NO₁₃
Molecular Weight	811.870
Flash Point	534.1±34.3 °C
Exact Mass	811.320374
PSA	215.22000
LogP	6.74
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.652
Storage condition	-20°C Freezer

Safety Phrases	24/25
HS Code	29329990

10-Deacetyl-7,1...

CAS#:114915-18-3

~89%

Deacetyltaxol

CAS#:78432-77-6

Literature: Mangatal; Adeline; Guenard; Gueritte-Voegelein; Potier Tetrahedron, 1989 , vol. 45, # 13 p. 4177 - 4190

Benzoyl chloride

CAS#:98-88-4

Deacetyltaxol

CAS#:78432-77-6

Literature: Tetrahedron, , vol. 45, # 13 p. 4177 - 4190

7,10-di-Troc-Do...

CAS#:114915-14-9

Deacetyltaxol

CAS#:78432-77-6

Literature: Tetrahedron, , vol. 45, # 13 p. 4177 - 4190

N/A

CAS#:197013-82-4

~9%

10-Deacetylbacc...

CAS#:32981-86-5

Deacetyltaxol

CAS#:78432-77-6

Paclitaxel

CAS#:33069-62-4

Detail

Literature: Chemistry Letters, , vol. 37, # 3 p. 362 - 363

Hydrogen peroxide

CAS#:7722-84-1

Paclitaxel

CAS#:33069-62-4

~98%

Deacetyltaxol

CAS#:78432-77-6

Literature: Hauser, Inc. Patent: US5629433 A1, 1997 ;

Paclitaxel

CAS#:33069-62-4

~95%

Deacetyltaxol

CAS#:78432-77-6

Literature: Zheng, Qun Y.; Darbie, Lynn G.; Cheng, Xiaoqin; Murray, Christopher K. Tetrahedron Letters, 1995 , vol. 36, # 12 p. 2001 - 2004

N/A

CAS#:197013-82-4

~5%

Deacetyltaxol

CAS#:78432-77-6

Paclitaxel

CAS#:33069-62-4

Literature: Chemistry Letters, , vol. 37, # 3 p. 362 - 363

N-Des-t-boc-10-...

CAS#:114915-16-1

Deacetyltaxol

CAS#:78432-77-6

Literature: Tetrahedron, , vol. 45, # 13 p. 4177 - 4190

Precursor 5
CAS#:7722-84-1 Hydrogen peroxide CAS#:33069-62-4 Paclitaxel CAS#:114915-16-1 N-Des-t-boc-10-... CAS#:98-88-4 Benzoyl chloride
CAS#:114915-14-9 7,10-di-Troc-Do...
DownStream 3
CAS#:32981-86-5 10-Deacetylbacc... CAS#:33069-62-4 Paclitaxel CAS#:92950-40-8 2'-acetyltaxol

benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

7-epi-10-deacetyltaxol

b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester

(2α,5β,7β,10β,13α)-4-(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

7-EPI-10-DEACETYL PACLITAXEL

10-DEACETYLTAXOL

10-Desacetyl Paclitaxel

(2α,5β,7β,10β,13α)-4-Acetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

10-Desacetyltaxol

Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,1 3-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

10-Deacetylpaclitaxel

10-DAT

BioBioPha
China
Product Name: Deacetyltaxol
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Deacetyltaxol
Price: ￥1920.0/5mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 10-Deacetylpaclitaxel
Price: $550.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: DEACETYLTAXOL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Deacetyltaxol
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Deacetyltaxol

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