10-去乙酰紫杉醇

• 常用名: 10-去乙酰紫杉醇
• 英文名: Deacetyltaxol
• CAS号: 78432-77-6
• 分子量: 811.870
• 密度: 1.4±0.1 g/cm3
• 沸点: 959.5±65.0 °C at 760 mmHg
• 分子式: C₄₅H₄₉NO₁₃
• 熔点: 182-184ºC
• 闪点: 534.1±34.3 °C

10-去乙酰紫杉醇用途

10-Deacetyltaxol (10-Deacetylpaclitaxel) 是从红豆杉中分离得到的一种紫杉醇衍生物。10-Deacetyltaxol (10-Deacetylpaclitaxel) 能促进微管蛋白的聚合,在体外抑制由冷或钙离子诱导的微管解聚。10-Deacetyltaxol (10-Deacetylpaclitaxel) 对人脑胶质细胞瘤和神经母细胞瘤细胞具有细胞毒性。

10-去乙酰紫杉醇名称

• 中文名: 7-表-10-脱乙酰基紫杉醇
• 英文名: Deacetyltaxol
• 中文别名: 7-表-去乙酰基紫杉醇 | 10-去乙酰基紫杉醇 | 10-去乙酰紫杉醇 | 10-脱乙酰基紫杉醇 | 10-去乙酰-7-差向紫杉醇 | 7-表-10-去乙酰基紫杉 | 7-表-10-去乙酰基紫杉醇 | 7-表-10-去乙酰基紫杉醇

10-去乙酰紫杉醇生物活性

• 描述: 10-Deacetyltaxol (10-Deacetylpaclitaxel) 是从红豆杉中分离得到的一种紫杉醇衍生物。10-Deacetyltaxol (10-Deacetylpaclitaxel) 能促进微管蛋白的聚合,在体外抑制由冷或钙离子诱导的微管解聚。10-Deacetyltaxol (10-Deacetylpaclitaxel) 对人脑胶质细胞瘤和神经母细胞瘤细胞具有细胞毒性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
• 靶点:

  tubulin[2]

• 参考文献:

  [1]. 19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana. J Nat Prod. 1981 May-Jun;44(3):312-9.

  [2]. Michel Colin, et al. Process for the preparation of taxol and 10-deacetyltaxol. US4857653A.

  [3]. Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9.

10-去乙酰紫杉醇物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 959.5±65.0 °C at 760 mmHg
• 熔点: 182-184ºC
• 分子式: C₄₅H₄₉NO₁₃
• 分子量: 811.870
• 闪点: 534.1±34.3 °C
• 精确质量: 811.320374
• PSA: 215.22000
• LogP: 6.74
• InChIKey: TYLVGQKNNUHXIP-MHHARFCSSA-N
• SMILES: CC(=O)OC12COC1CC(O)C1(C)C(=O)C(O)C3=C(C)C(OC(=O)C(O)C(NC(=O)c4ccccc4)c4ccccc4)CC(O)(C(OC(=O)c4ccccc4)C21)C3(C)C
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.652
• 储存条件: -20°C Freezer

10-去乙酰紫杉醇安全信息

• 安全声明 (欧洲): 24/25
• 海关编码: 29329990

10-去乙酰紫杉醇英文别名

• benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• 7-epi-10-deacetyltaxol
• b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
• (2α,5β,7β,10β,13α)-4-(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 7-EPI-10-DEACETYL PACLITAXEL
• 10-DEACETYLTAXOL
• 10-Desacetyl Paclitaxel
• (2α,5β,7β,10β,13α)-4-Acetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 10-Desacetyltaxol
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,1 3-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• 10-Deacetylpaclitaxel
• 10-DAT