Taxol, 10-deacetyl taxol and their related side chain analogues can be obtained via a “Sharpless” oxyamination reaction on 13-cinnamoyl baccatin III. Asymmetric induction has been studied using different bridgehead amines as chiral ligands. This procedure constitutes an alternative route to taxol derivatives for biological studies.
[Nevarez, Danielle M.; Mengistu, Yemane A.; Nawarathne, Irosha N.; Walker, Kevin D. Journal of the American Chemical Society, 2009 , vol. 131, p. 5994 - 6002]
![N-Des-t-boc-10-deacetyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel Structure](https://image.chemsrc.com/caspic/353/114915-16-1.png)