Urapidil Hydrochloride
Urapidil Hydrochloride structure
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Common Name | Urapidil Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 64887-14-5 | Molecular Weight | 423.937 | |
| Density | N/A | Boiling Point | 549ºC at 760 mmHg | |
| Molecular Formula | C20H30ClN5O3 | Melting Point | 156-158ºC | |
| MSDS | Chinese USA | Flash Point | 285.8ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Facilitation of expulsion of ureteral stones by addition of α1-blockers to conservative therapy.
Scand. J. Urol. Nephrol. 44(6) , 420-4, (2010) An antispasmodic agent and a medicine that facilitates stone expulsion are given commonly as conservative therapy for ureteral stones in Japan. The goal of this study was to compare the efficacy of the addition of various α(1)-blockers to the conservative the... |
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Capillary electrophoresis with end-column electrochemiluminescence for ultrasensitive determination of urapidil hydrochloride in rat plasma and its application to pharmacokinetics study.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1006 , 146-50, (2015) A simple, sensitive and selective method for determination of urapidil hydrochloride was developed using capillary electrophoresis with electrochemiluminescence (CE-ECL) technique for the first time. Under the optimized experimental conditions, the ECL intens... |
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[Hypertensive crisis in cardiology: place of urapidil].
Kardiologiia 52(1) , 86-90, (2012)
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Urapidil, a dual-acting antihypertensive agent: Current usage considerations.
Adv. Ther. 27(7) , 426-43, (2010) Despite the availability of a wide range of effective blood pressure (BP)-lowering agents, a substantial proportion of patients with hypertension fail to achieve target BP levels. The majority of patients with hypertension need a combination of two or more dr... |
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Effects of α1-adrenoceptor antagonists on phenylephrine-induced salivary secretion and intraurethral pressure elevation in anesthetized rats.
Eur. J. Pharmacol. 679(1-3) , 127-31, (2012) α(1)-Adrenoceptor antagonists are widely used for the treatment of voiding dysfunction associated with benign prostatic hyperplasia. Activation of α(1)-adrenoceptors is reported to induce salivary secretion in rats and humans. However, the effects of α(1)-adr... |
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Synthesis of a quinazoline derivative: a new α₁-adrenoceptor ligand for conjugation to quantum dots to study α₁-adrenoceptors in living cells.
Bioorg. Med. Chem. Lett. 21(19) , 5905-9, (2011) Quantum dots (QDs) that are conjugated to small molecule derivatives of drugs and endogenous ligands may be useful tools to study the distribution and dynamic of membrane bound receptors, ion channels and transporters in live cells. In order to use these tool... |
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Preparation for surgery of phaeochromocytoma by blockade of alpha-adrenergic receptors with urapidil: what dose?
J. Hum. Hypertens. 23(9) , 605-9, (2009) The preparation for phaeochromocytoma surgery is a matter of debate. Pre-operative blockade of alpha-1 receptors is increasingly employed in an attempt to reduce the risk of hypertensive episodes, especially during manipulation of the tumour. In this study, w... |
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Decrease in blood pressure after intravenous administration of urapidil during recombinant tissue plasminogen activator thrombolysis for acute ischemic stroke.
Clin. Ther. 30(9) , 1675-80, (2008) In patients who are candidates for IV recombinant tissue plasminogen activator (rtPA) thrombolysis for the treatment of acute ischemic stroke, blood pressure (BP)-lowering therapy is sometimes needed for systolic BP >185 mm Hg or diastolic BP >110 mm Hg. Howe... |
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Effects of vasoactive substances on the neurovascular structures and microcirculation in the developing callus 10 and 15 days after bone injury.
Clin. Hemorheol. Microcirc. 50(4) , 279-91, (2012) The developing callus requires sufficient oxygen and substrate supply. Despite the importance of these processes, we have limited understanding of regulation of the callus microcirculation. We aimed to assess the role of vasoactive substances in the microcirc... |
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Quantification of urapidil, α-1-adrenoreceptor antagonist, in plasma by LC-MS/MS: validation and application to pharmacokinetic studies.
Biomed. Chromatogr. 25(12) , 1319-26, (2011) A sensitive high-performance liquid chromatography-positive ion electrospray tandem mass spectrometry method was developed and validated for the quantification of urapidil in plasma. Following liquid-liquid extraction, the analyte was separated using an isocr... |