calpeptin
calpeptin structure
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Common Name | calpeptin | ||
|---|---|---|---|---|
| CAS Number | 117591-20-5 | Molecular Weight | 362.463 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 550.7±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H30N2O4 | Melting Point | 60-75 °C | |
| MSDS | USA | Flash Point | 286.8±28.7 °C | |
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Calpain mediates processing of the translation termination factor eRF3 into the IAP-binding isoform p-eRF3.
FEBS Lett. 589 , 2241-7, (2015) The involvement of polypeptide chain-releasing factor eRF3 in translation termination and mRNA decay is well established. Moreover, the finding that the proteolytically processed isoform of eRF3 (p-eRF3) interacts with inhibitors of apoptosis proteins (IAPs) ... |
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Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.
J. Clin. Invest. 125(3) , 1098-110, (2015) The intracellular protein HMGB1 is released from cells and acts as a damage-associated molecular pattern molecule during many diseases, including inflammatory bowel disease (IBD); however, the intracellular function of HMGB1 during inflammation is poorly unde... |
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Salbutamol inhibits RhoA activation in normal but not in desensitized bronchial smooth muscle cells.
J. Pharm. Pharmacol. 67 , 1416-20, (2015) This study was aimed at investigating whether the β2 -adrenoceptor agonist, salbutamol, could modulate RhoA activation in normal and homologously desensitized bronchial smooth muscle cells (BSMC).Serum-starved BSMCs were stimulated with the Rho-activating com... |
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NCYM promotes calpain-mediated Myc-nick production in human MYCN-amplified neuroblastoma cells.
Biochem. Biophys. Res. Commun. 461 , 501-6, (2015) NCYM is a cis-antisense gene of MYCN and is amplified in human neuroblastomas. High NCYM expression is associated with poor prognoses, and the NCYM protein stabilizes MYCN to promote proliferation of neuroblastoma cells. However, the molecular mechanisms of N... |
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Berbamine protects the heart from ischemia/reperfusion injury by maintaining cytosolic Ca(2+) homeostasis and preventing calpain activation.
Circ. J. 76(8) , 1993-2002, (2012) Berbamine, a natural compound from Barberry, was reported to protect myocardium from ischemia/reperfusion (I/R) injury, but the underlying mechanisms are largely unknown.Berbamine pretreatment from 10 to 100nmol/L concentration-dependently improved post-ische... |
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Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.
PLoS ONE 7(3) , e33468, (2012) Calpains are calcium regulated cysteine proteases that have been described in a wide range of cellular processes, including apoptosis, migration and cell cycle regulation. In addition, calpains have been implicated in differentiation, but their impact on neur... |
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Demethylation and re-expression of epigenetically silenced tumor suppressor genes: sensitization of cancer cells by combination therapy.
Epigenomics 5(1) , 87-94, (2013) Epigenetic regulation in eukaryotic and mammalian systems is a complex and emerging field of study. While histone modifications create an open chromatin conformation allowing for gene transcription, CpG methylation adds a further dimension to the expression o... |
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Calpain inhibition attenuates apoptosis of retinal ganglion cells in acute optic neuritis.
Invest. Ophthalmol. Vis. Sci. 52(7) , 4935-41, (2011) Optic neuritis (ON), inflammation of the optic nerve, is strongly associated with the pathogenesis of multiple sclerosis (MS) and is initiated by the attack of autoreactive T cells against self-myelin antigens, resulting in demyelination, degeneration of reti... |
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Calpain inhibitor attenuated optic nerve damage in acute optic neuritis in rats.
J. Neurochem. 124(1) , 133-46, (2013) Optic neuritis (ON), which is an acute inflammatory autoimmune demyelinating disease of the central nervous system (CNS), often occurs in multiple sclerosis (MS). ON is an early diagnostic sign in most MS patients caused by damage to the optic nerve leading t... |
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Neuroprotective effects of MAPK/ERK1/2 and calpain inhibitors on lactacystin-induced cell damage in primary cortical neurons
Neurotoxicology 32(6) , 845-56, (2011) Highlights ► MAPK/ERK1/2 and calpain inhibitors attenuated the lactacystin-induced cell death in primary cortical neurons. ► Protection mediated by MAPK/ERK1/2 and calpain inhibitors were connected with attenuation of lactacystin-evoked DNA fragmentation with... |