NeuroToxicology 2011-12-01

Neuroprotective effects of MAPK/ERK1/2 and calpain inhibitors on lactacystin-induced cell damage in primary cortical neurons

D. Jantas, E. Lorenc-Koci, M. Kubera, W. Lason

Index: Neurotoxicology 32(6) , 845-56, (2011)

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Abstract

Highlights ► MAPK/ERK1/2 and calpain inhibitors attenuated the lactacystin-induced cell death in primary cortical neurons. ► Protection mediated by MAPK/ERK1/2 and calpain inhibitors were connected with attenuation of lactacystin-evoked DNA fragmentation without affecting the caspase-3 activity. ► The protective effects of MAPK/ERK1/2, but not calpain inhibitors were connected with attenuation of AIF protein level in cytosolic and nuclear fraction.