zerumbone
zerumbone structure
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Common Name | zerumbone | ||
|---|---|---|---|---|
| CAS Number | 471-05-6 | Molecular Weight | 218.335 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 321.6±42.0 °C at 760 mmHg | |
| Molecular Formula | C15H22O | Melting Point | 67-69℃ | |
| MSDS | Chinese USA | Flash Point | 133.9±22.8 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis.
Cell. Mol. Life Sci. 68(6) , 1033-40, (2011) Plant cytochrome P450s are involved in the biosynthesis of various classes of secondary metabolites. To elucidate the biosynthesis of zerumbone, a sesquiterpenoid with multiple potential anticancer properties, a family of P450 genes expressed in rhizomes of Z... |
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Altered cross-linking of HSP27 by zerumbone as a novel strategy for overcoming HSP27-mediated radioresistance.
Int. J. Radiat. Oncol. Biol. Phys. 79(4) , 1196-205, (2011) HSP27 or HSP25 negatively regulates apoptosis pathways after radiation or chemotherapeutic agents. Abrogation of HSP27 function may be a candidate target for overcoming radio- and chemoresistance.Zerumbone (ZER), a cytotoxic component isolated from Zingiber z... |
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Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p'-DDT in U937 macrophages.
Arch. Toxicol. 84(12) , 957-66, (2010) To assess the effectiveness of selected food phytochemicals in reducing the toxic effects of the environmental toxicants, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and p,p'-DDT (DDT), we tested the potencies of auraptene, nobiletin, zerumbone, and (±)-13-hyd... |
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Ginger phytochemicals mitigate the obesogenic effects of a high-fat diet in mice: a proteomic and biomarker network analysis.
Mol. Nutr. Food. Res. 55 Suppl 2 , S203-13, (2011) Natural dietary anti-obesogenic phytochemicals may help combat the rising global incidence of obesity. We aimed to identify key hepatic pathways targeted by anti-obsogenic ginger phytochemicals fed to mice.Weaning mice were fed a high-fat diet containing 6-gi... |
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Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice.
Fitoterapia 81(7) , 855-8, (2010) The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated t... |
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Cytotoxicity against cholangiocarcinoma cell lines of zerumbone derivatives.
Eur. J. Med. Chem. 45 , 3794-802, (2010) Cholangiocarcinoma (CCA) is an aggressive malignancy with a very high morbidity and mortality for which an effective treatment is lacking. In this study, seventeen zerumbone derivatives were synthesized and evaluated for in vitro cytotoxicity against cholangi... |
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Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells.
Leuk. Res. 35(2) , 268-71, (2011) Zerumbone (ZER) is a potential anticancer natural compound, isolated from Zingiber zerumbet Smith. In this investigation, the anticancer properties of ZER were evaluated on cancer cells of T-acute lymphoblastic leukemia, CEM-ss. The results showed that ZER ha... |
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Zerumbone-induced antinociception: involvement of the L-arginine-nitric oxide-cGMP -PKC-K+ ATP channel pathways.
Basic Clin Pharmacol Toxicol. 108(3) , 155-62, (2011) This study investigated the antinociceptive effects of zerumbone in chemical behavioural models of nociception in mice. Zerumbone given through intraperitoneal route (i.p.) produced dose-related antinociception when assessed on acetic acid-induced abdominal w... |
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Dietary zerumbone prevents against ultraviolet B-induced cataractogenesis in the mouse.
Mol. Vis. 17 , 723-30, (2011) To investigate the preventive effect of dietary zerumbone against UVB-induced cataractogenesis.A total of 50 six-week-old female ICR mice were split into five groups (each contained 10 mice) and exposed to UVB (0.72 J/cm(2)/daily) at noon for 7 days, except f... |
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Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells.
J. Biomed. Sci. 19 , 86, (2012) Zerumbone, a sesquiterpene compound isolated from subtropical ginger, Zingiber zerumbet Smith, has been documented to exert antitumoral and anti- inflammatory activities. In this study, we demonstrate that zerumbone induces apoptosis in human glioblastoma mul... |