Fitoterapia 2010-10-01

Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice.

M R Sulaiman, E K Perimal, M N Akhtar, A S Mohamad, M H Khalid, N A Tasrip, F Mokhtar, Z A Zakaria, N H Lajis, D A Israf

Index: Fitoterapia 81(7) , 855-8, (2010)

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Abstract

The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test.Copyright © 2010 Elsevier B.V. All rights reserved.