7-(2-Hydroxyethyl)theophylline
7-(2-Hydroxyethyl)theophylline structure
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Common Name | 7-(2-Hydroxyethyl)theophylline | ||
|---|---|---|---|---|
| CAS Number | 519-37-9 | Molecular Weight | 224.21700 | |
| Density | 1.51g/cm3 | Boiling Point | 495.5ºC at 760mmHg | |
| Molecular Formula | C9H12N4O3 | Melting Point | 163°C | |
| MSDS | Chinese USA | Flash Point | 253.5ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods.
Eur. J. Med. Chem. 45 , 3459-71, (2010) Ligand-based and receptor-based methods were used to investigate the binding modes of human adenosine A(2B) antagonists. At first, pharmacophore models were developed based on 140 diverse A(2B) antagonists from literature. Meanwhile, the structural model of A... |
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A simple and rapid HPLC/UV method for the simultaneous quantification of theophylline and etofylline in human plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 848(2) , 271-6, (2007) A simple, sensitive and selective high performance liquid chromatography (HPLC) method with ultraviolet detection (272 nm) was developed and validated for the simultaneous quantification of theophylline and etofylline in human plasma. Following rapid sample p... |
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Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats.
Naunyn Schmiedebergs Arch. Pharmacol. 356(1) , 48-55, (1997) The behavioural and electrocorticographic (ECoG) convulsant effects of several xanthine derivatives injected intraperitoneally (i.p.) were studied in genetically-epilepsy prone rats. The aim of the study was to evaluate the relationship among convulsant poten... |
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Pharmacological studies in animals of beta-hydroxyethyltheophylline, the major metabolite of doxofylline in humans.
Methods Find. Exp. Clin. Pharmacol. 13(4) , 289-99, (1991) beta-HET (beta-Hydroxyethyltheophylline), the major metabolite of the antibronchospastic, antiasthmatic drug doxofylline was studied in several in vitro and in vivo trials to characterize its pharmaco-toxicological profile. When compared to the parent compoun... |
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Investigation of the aqueous dissolution of semicrystalline poly(ethylene oxide) using infrared chemical imaging: the effects of molecular weight and crystallinity.
Appl. Spectrosc. 59(8) , 976-85, (2005) Fourier transform infrared (FT-IR) imaging was used to successfully explore several factors influencing the dissolution of poly(ethylene oxide). The effect of the degree of crystallinity on the rate of dissolution of mid-range molecular weight PEO was negligi... |
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Solid phase extraction and high performance liquid chromatographic determination of doxophylline in plasma.
Biomed. Chromatogr. 4(5) , 205-7, (1990) A sensitive and selective high performance liquid chromatographic doxophylline assay with ultraviolet detection has been developed for plasma samples. The drug is isolated from biological samples with a reversed phase C18 disposable extraction column. Plasma ... |
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[Stability of oxyethyltheophylline solutions for injection].
Pharmazie 39(1) , 24-6, (1984) The testing of oxyethyltheophylline solutions for injection involved the separate study of their constituents, theophylline and ethophylline, particular attention being given to the behaviour of both these active agents under thermal stress in acid or alkalin... |
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Prodrugs of theophylline incorporating ethyleneoxy groups in the promoiety: synthesis, characterization, and transdermal delivery.
AAPS PharmSciTech 13(3) , 853-62, (2012) Two different types of derivatives of theophylline (Th-H) incorporating ethyleneoxy groups into the promoiety have been synthesized. One is a soft alkyl type where N-methyl-N-methoxyethyleneoxycarbonylaminomethyl chlorides have been used to alkylate Th-H in t... |
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Altered vitamin B6 homeostasis during aminophylline infusion in the beagle dog.
Int. J. Vitam. Nutr. Res. 60(1) , 35-40, (1990) The effect of intravenous infusion of aminophylline, a strong inhibitor of pyridoxal kinase, on intra- and extracellular vitamin B6 homeostasis was investigated in four beagle dogs. Plasma and erythrocyte pyridoxal levels increased by 118% and 117% respective... |
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Simultaneous determination of multi drug components Theophylline, Etofylline, Guaiphenesine and Ambroxol Hydrochloride by validated RP-HPLC method in liquid dosage form.
Pak. J. Pharm. Sci. 21(2) , 151-8, (2008) The RP-HPLC (reverse phase high performance liquid chromatography) method was developed and validated for simultaneous determination of Multi drug components i.e., Theophylline, Etofylline, Guaiphenesine and Ambroxol Hydrochloride in a liquid dosage form. Chr... |