LY 171883
LY 171883 structure
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Common Name | LY 171883 | ||
|---|---|---|---|---|
| CAS Number | 88107-10-2 | Molecular Weight | 318.37 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 553.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C16H22N4O3 | Melting Point | 117-119℃ | |
| MSDS | Chinese USA | Flash Point | 288.3±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Role of leukotrienes in N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in male Fischer 344 rats.
Toxicology 300(1-2) , 92-9, (2012) The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) can induce marked nephrotoxicity in rats following a single intraperitoneal (ip) administration of 0.4mmol/kg or greater. Although NDPS induces direct renal proximal tubular toxicity, a role ... |
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Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa.
Prostaglandins 51(1) , 69-79, (1996) To clarify the effects of leukotriene C4 (LTC4) on human ciliated epithelium, ciliary activity of the ethmoid sinus mucosa was measured photoelectrically in tissue culture. At concentrations ranging from 10(-6)M to 10(-9)M, LTC4 showed minimal effects on the ... |
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Blood cell-vascular wall interactions and the production of coronary contracting sulfidopeptide leukotrienes in isolated, cell- perfused, rabbit heart.
Adv. Prostaglandin. Thromboxane. Leukot. Res. 23 , 385-7, (1995)
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The G protein-coupled receptor CysLT1 mediates chemokine-like effects and prolongs survival in chronic lymphocytic leukemia.
Leuk. Lymphoma 53(4) , 665-73, (2012) The G protein-coupled receptor (GPCR) CXCR4 is involved in bone marrow tropism and survival of chronic lymphocytic leukemia (CLL) cells. The function of the GPCRs cysteinyl leukotriene receptor 1 (CysLT1) and CysLT2 remains elusive. Here we demonstrate that i... |
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Furosemide attenuates bronchial responsiveness to antigen challenge "in vitro".
Adv. Prostaglandin. Thromboxane. Leukot. Res. 23 , 365-7, (1995)
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Beneficial effects of combined thromboxane and leukotriene receptor antagonism in hemorrhagic shock.
Crit. Care Med. 23(2) , 231-7, (1995) Both thromboxane A2 and peptide leukotrienes D4/E4 have been implicated in the pathophysiology of circulatory shock. In the present study, we evaluated the effect of thromboxane A2 and leukotriene D4/E4 receptor antagonism in circulatory shock.Prospective, ra... |
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Common structural requirements for peroxisome proliferation by tetrazole and carboxylic acid-containing compounds.
Ann. N. Y. Acad. Sci. 804 , 387-402, (1996)
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Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine.
Eur. J. Pharmacol. 459(1) , 27-39, (2003) Conventional intracellular microelectrodes, neuronal tracer injection techniques and immunohistochemistry were used to study the actions of cysteinyl leukotrienes (CysLTs) on electrical and synaptic behavior of enteric neurons in guinea-pig stomach and small ... |
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Contractile responses to allergen and cholinergic stimulation in bronchus and trachea of cockroach allergen-sensitized guinea pigs.
Int. Arch. Allergy Immunol. 116(2) , 132-9, (1998) Airway hyperreactivity is a hallmark of asthma. Yet, the role of allergic sensitization in the hyperreactivity remains controversial. This study examined the effects of airborne cockroach allergen (CRa) sensitization on the contractility of bronchial (BSM) an... |
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Protective effect of peptide leukotriene antagonist on renal failure induced by a tourniquet in rabbits.
Forensic Sci. Int. 71(1) , 57-64, (1995) We studied the effects of a selective antagonist of peptide leukotriene D4/E4 (LY-171883) and 5-lipoxygenase inhibitor diethylcarbamazine (DEC) in renal failure induced by a tourniquet, because peptide leukotrienes (LTs) were suggested to play a key role in o... |