LY 171883

Modify Date: 2025-08-22 12:20:42

LY 171883 structure	Common Name	LY 171883
	CAS Number	88107-10-2	Molecular Weight	318.37
	Density	1.2±0.1 g/cm3	Boiling Point	553.0±60.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₂₂N₄O₃	Melting Point	117-119℃
	MSDS	Chinese USA	Flash Point	288.3±32.9 °C
	Symbol	GHS07	Signal Word	Warning

Use of LY 171883

Tomelukast (LY171883) is an orally active leukotriene D4 and E4 antagonist. Tomelukast can be used for the research of asthma[1].

Name	tomelukast
Synonym	More Synonyms

Description	Tomelukast (LY171883) is an orally active leukotriene D4 and E4 antagonist. Tomelukast can be used for the research of asthma[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
Target	leukotriene D4, leukotriene E4[1]
References	[1]. Abraham WM, et al. The effect of an orally active leukotriene D4/E4 antagonist, LY171883, on antigen-induced airway responses in allergic sheep. Prostaglandins. 1986 Mar;31(3):457-67.

Density	1.2±0.1 g/cm3
Boiling Point	553.0±60.0 °C at 760 mmHg
Melting Point	117-119℃
Molecular Formula	C₁₆H₂₂N₄O₃
Molecular Weight	318.37
Flash Point	288.3±32.9 °C
Exact Mass	318.169189
PSA	100.99000
LogP	3.27
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.574
Storage condition	Store at +4°C

LY 171883 MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM5780800

CHEMICAL NAME :: Ethanone, 1-(2-hydroxy-3-propyl-4-(4-(1H-tetrazol-5-yl)butoxy)p henyl)-

CAS REGISTRY NUMBER :: 88107-10-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H22-N4-O3

MOLECULAR WEIGHT :: 318.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18250 mg/kg/1Y-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Effect on specific coenzyme - NAD,NADP

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3010 mg/kg/2W-C

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Metabolism (Intermediary) - lipids including transport

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 63875 mg/kg/1Y-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 1260 mg/kg/1W (Continuous)

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1557,1991

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KM5780800

N/A

CAS#:92518-07-5

~76%

LY 171883

CAS#:88107-10-2

Literature: Bernstein; Vacek Synthesis, 1987 , # 12 p. 1133 - 1134

Carbon

CAS#:7440-44-0

N/A

CAS#:92518-07-5

LY 171883

CAS#:88107-10-2

Literature: US4661505 A1, ;

Precursor 1
CAS#:7440-44-0 Carbon
DownStream 0

Role of leukotrienes in N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in male Fischer 344 rats.

Toxicology 300(1-2) , 92-9, (2012)

The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) can induce marked nephrotoxicity in rats following a single intraperitoneal (ip) administration of 0.4mmol/kg or greater. Although N...

Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa.

Prostaglandins 51(1) , 69-79, (1996)

To clarify the effects of leukotriene C4 (LTC4) on human ciliated epithelium, ciliary activity of the ethmoid sinus mucosa was measured photoelectrically in tissue culture. At concentrations ranging f...

Blood cell-vascular wall interactions and the production of coronary contracting sulfidopeptide leukotrienes in isolated, cell- perfused, rabbit heart.

Adv. Prostaglandin. Thromboxane. Leukot. Res. 23 , 385-7, (1995)

MFCD00211057

Ethanone, 1-[2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]-

Tomelukast

1-[2-hydroxy-3-propyl-4-[4-(2H-tetrazol-5-yl)butoxy]phenyl]ethanone

1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl}ethanone

Tomelukastum

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: LY171883
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Tomelukast
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Tomelukast
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: LY 171883
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: LY 171883
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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LY 171883

Use of LY 171883

Names

LY 171883 Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

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Synonyms

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