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88107-10-2

88107-10-2 structure
88107-10-2 structure
  • Name: LY 171883
  • Chemical Name: tomelukast
  • CAS Number: 88107-10-2
  • Molecular Formula: C16H22N4O3
  • Molecular Weight: 318.37
  • Catalog: Surfactant Anionic surfactant Other anionic surfactants
  • Create Date: 2018-02-07 08:00:00
  • Modify Date: 2025-08-22 12:20:42
  • Tomelukast (LY171883) is an orally active leukotriene D4 and E4 antagonist. Tomelukast can be used for the research of asthma[1].
Name tomelukast
Synonyms MFCD00211057
Ethanone, 1-[2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]-
Tomelukast
1-[2-hydroxy-3-propyl-4-[4-(2H-tetrazol-5-yl)butoxy]phenyl]ethanone
1-{2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl}ethanone
Tomelukastum
Description Tomelukast (LY171883) is an orally active leukotriene D4 and E4 antagonist. Tomelukast can be used for the research of asthma[1].
Related Catalog
Target

leukotriene D4, leukotriene E4[1]

References

[1]. Abraham WM, et al. The effect of an orally active leukotriene D4/E4 antagonist, LY171883, on antigen-induced airway responses in allergic sheep. Prostaglandins. 1986 Mar;31(3):457-67.  

Density 1.2±0.1 g/cm3
Boiling Point 553.0±60.0 °C at 760 mmHg
Melting Point 117-119℃
Molecular Formula C16H22N4O3
Molecular Weight 318.37
Flash Point 288.3±32.9 °C
Exact Mass 318.169189
PSA 100.99000
LogP 3.27
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.574
Storage condition Store at +4°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KM5780800
CHEMICAL NAME :
Ethanone, 1-(2-hydroxy-3-propyl-4-(4-(1H-tetrazol-5-yl)butoxy)p henyl)-
CAS REGISTRY NUMBER :
88107-10-2
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C16-H22-N4-O3
MOLECULAR WEIGHT :
318.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
650 mg/kg
TOXIC EFFECTS :
Liver - other changes
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18250 mg/kg/1Y-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Effect on specific coenzyme - NAD,NADP
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3010 mg/kg/2W-C
TOXIC EFFECTS :
Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Metabolism (Intermediary) - lipids including transport
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
63875 mg/kg/1Y-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
1260 mg/kg/1W (Continuous)
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1557,1991
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases 36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS KM5780800
92518-07-5 structure

92518-07-5

~76%

88107-10-2 structure

88107-10-2

Literature: Bernstein; Vacek Synthesis, 1987 , # 12 p. 1133 - 1134
7440-44-0 structure

7440-44-0

92518-07-5 structure

92518-07-5

~%

88107-10-2 structure

88107-10-2

Literature: US4661505 A1, ;
Precursor  1

DownStream  0

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