137328-52-0

137328-52-0 structure

Name: LY 215840
Chemical Name: (6aR,9R)-N-[(1S,2R)-2-hydroxycyclopentyl]-7-methyl-4-propan-2-yl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
CAS Number: 137328-52-0
Molecular Formula: C₂₄H₃₃N₃O₂
Molecular Weight: 395.54
Create Date: 2016-01-28 12:52:12
Modify Date: 2025-09-15 19:56:39
LY215840, a 5-HT7 receptor ligand and a 5-HT2 receptor antagonist, blocks serotonin-induced relaxation in canine coronary artery[1][2].

Name	(6aR,9R)-N-[(1S,2R)-2-hydroxycyclopentyl]-7-methyl-4-propan-2-yl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
Synonyms	[Orn8]-Urotensin II Ergoline-8-carboxamide,N-(2-hydroxycyclopentyl)-6-methyl-1-(1-methylethyl)-,(8beta(1S,2R)) Ergoline-8-carboximide,N-(2-hydroxycyclopentyl)-6-methyl-1-(1-methylethyl)-,(8beta(1S,2R)) (4R,7R)-N-[(1S,2R)-2-hydroxycyclopentyl]-6-methyl-11-(propan-2-yl)-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraene-4-carboxamide

Description	LY215840, a 5-HT7 receptor ligand and a 5-HT2 receptor antagonist, blocks serotonin-induced relaxation in canine coronary artery[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT2 Receptor 5-HT7 Receptor
In Vitro	LY215840 (1 μM) markedly potentiated contraction to 5-carboxamidotryptamine, the most potent coronary relaxant agonist and the agonist with the highest 5-HT7 receptor affinity[1]. LY215840 (3 x 10-10 to 10-8 M) blocks 5-HT2 receptors mediating contraction to 5-HT in vitro[2].
References	[1]. D J Cushing, et al. LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery. J Pharmacol Exp Ther. 1996 Jun;277(3):1560-6. [2]. M L Cohen , et al. LY215840, a potent 5-hydroxytryptamine (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2 receptors and delays occlusion in a rabbit model of thrombosis. J Pharmacol Exp Ther. 1992 Apr;261(1):202-8.