bis(3-aminopropyl)amine
bis(3-aminopropyl)amine structure
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Common Name | bis(3-aminopropyl)amine | ||
|---|---|---|---|---|
| CAS Number | 56-18-8 | Molecular Weight | 131.219 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 242.1±0.0 °C at 760 mmHg | |
| Molecular Formula | C6H17N3 | Melting Point | −14 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 118.3±0.0 °C | |
| Symbol |
GHS05, GHS06, GHS08 |
Signal Word | Danger | |
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Nitric oxide induces cancer stem cell-like phenotypes in human lung cancer cells.
Am. J. Physiol. Cell Physiol. 308(2) , C89-100, (2015) Even though tremendous advances have been made in the treatment of cancers during the past decades, the success rate among patients with cancer is still dismal, largely because of problems associated with chemo/radioresistance and relapse. Emerging evidence h... |
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Norspermidine and novel Pd(II) and Pt(II) polynuclear complexes of norspermidine as potential antineoplastic agents against breast cancer.
PLoS ONE 8(2) , e55651, (2013) New strategies are needed for breast cancer treatment and one initial step is to test new chemotherapeutic drugs in breast cancer cell lines, to choose candidates for further studies towards clinical use.The cytotoxic effects of a biogenic polyamine analogue ... |
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Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era.
Cold Spring Harb. Perspect. Med. 3(4) , a010306, (2013) Biofilm formation constitutes an alternative lifestyle in which microorganisms adopt a multicellular behavior that facilitates and/or prolongs survival in diverse environmental niches. Biofilms form on biotic and abiotic surfaces both in the environment and i... |
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The binding of polyamines and magnesium to DNA.
J. Inorg. Biochem. 46(2) , 87-97, (1992) 1. The binding of spermine and Mg2+ to DNA has been investigated using the dye arsenazo III to measure unbound cations. 2. The apparent dissociation constant, Kd, of DNA for spermine has been found to be 7.4 +/- 3.9 x 10(-8) M and that for Mg2+, 6.5 +/- 3.3 x... |
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Norspermidine inhibits LPS-induced immunoglobulin production in an FCS-independent mechanism different from spermidine and spermine
Int. J. Immunopharmacol. 13(1) , 67-73, (1991) The immunosuppressive effects of several polyamines were compared. The triamines (norspermidine (NSPD) and spermidine (SPD)) and the tetramines (norspermine (NSPM) and spermine (SPM)) but not the diamines (1,3-diaminopropane and putrescine) inhibited IgM prod... |
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Mechanism and structure-activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase.
Bioorg. Med. Chem. 13(14) , 4513-26, (2005) A library of polyamine-peptide conjugates based around some previously identified inhibitors of trypanothione reductase was synthesised by parallel solid-phase chemistry and screened. Kinetic analysis of library members established that subtle structural chan... |
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Elevated levels of the norspermidine synthesis enzyme NspC enhance Vibrio cholerae biofilm formation without affecting intracellular norspermidine concentrations.
FEMS Microbiol. Lett. 329(1) , 18-27, (2012) Biofilm formation in Vibrio cholerae is in part regulated by norspermidine, a polyamine synthesized by the enzyme carboxynorspermidine decarboxylase (NspC). The absence of norspermidine in the cell leads to a marked reduction in V. cholerae biofilm formation ... |
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Purification and characterization of polyamine aminotransferase of Arthrobacter sp. TMP-1.
J. Biochem. 122(3) , 537-43, (1997) Polyamine aminotransferase of Arthrobacter sp. TMP-1 was induced by 1,3-diaminopropane (DAP), N-3-aminopropyl-1,3-diaminopropane (norspermidine), spermidine, and spermine, but not by putrescine. The enzyme was purified to homogeneity. Its molecular weight and... |
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Antitumor activity of norspermidine, a structural homologue of the natural polyamine spermidine.
Anticancer Res. 8(4) , 563-8, (1988) The structural specificities of the natural polyamines putrescine (Put), spermidine (Spd) and spermine (Spm) for cell growth are rather stringent, suggesting that appropriate structural analogues of these polycations could serve as potential antineoplastic ag... |
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Further study on polyamine compositions in Vibrionaceae.
Can. J. Microbiol. 37(2) , 148-53, (1991) It has previously been reported that norspermidine, one of the unusual polyamines, is present in Vibrio species. To expand this observation, the cellular polyamine compositions of additional species and strains in the family Vibrionaceae (Vibrio, Photobacteri... |